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Pregled bibliografske jedinice broj: 1230362

Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions


Tadijan, Ana; Vlašić, Ignacija; Vlainić, Josipa; Đikić, Domagoj; Oršolić, Nada; Jazvinšćak Jembrek, Maja
Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions // Antioxidants, 11 (2022), 10; 2049, 36 doi:10.3390/antiox11102049 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions

Autori
Tadijan, Ana ; Vlašić, Ignacija ; Vlainić, Josipa ; Đikić, Domagoj ; Oršolić, Nada ; Jazvinšćak Jembrek, Maja

Izvornik
Antioxidants (2076-3921) 11 (2022), 10; 2049, 36

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Cannabinoids ; Neuroprotection ; Redox-sensitive signalling pathways ; Oxidative stress ; Neuroinflammation

Sažetak
In the last few decades, endocannabinoids, plant-derived cannabinoids and synthetic cannabinoids have received growing interest as treatment options in neurodegenerative conditions. In various experimental settings, they have displayed antioxidative, anti-inflammatory, antiapoptotic, immunomodulatory, and neuroprotective effects. However, due to numerous targets and downstream effectors of their action, the cellular and molecular mechanisms underlying these effects are rather complex and still under discussion. Cannabinoids are able to neutralize free radicals and modulate the production of reactive oxygen species and the activity of antioxidative systems acting on CB1 and CB2 cannabinoid receptors. The activation of CB1 receptors stimulates signaling pathways involved in antioxidative defense and survival (such as the phosphoinositide 3-kinase (PI3K)/Akt, mitogen-activated protein kinase (MAPK), and Nrf2 pathways) and regulates glutamatergic signaling, the activation of N-methyl-D-aspartate (NMDA) receptors, calcium influx, and the induction of Ca2+-regulated signaling cascades, whereas the neuroprotective effects mediated by CB2 receptors are due to the suppression of microglial activation and the release of prooxidative and proinflammatory mediators. This review summarizes the main molecular mechanisms and new advances in understanding the antioxidative and neuroprotective effects of cannabinoids. Because of the plethora of possible pharmacological interventions related to oxidative stress and cannabinoid-mediated neuroprotection, future research should be directed towards a better understanding of the interplay between activated signal transduction pathways and molecular targets with the aim to improve treatment options and efficacy by targeting the endocannabinoid system.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Hrvatsko katoličko sveučilište, Zagreb

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com

Citiraj ovu publikaciju:

Tadijan, Ana; Vlašić, Ignacija; Vlainić, Josipa; Đikić, Domagoj; Oršolić, Nada; Jazvinšćak Jembrek, Maja
Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions // Antioxidants, 11 (2022), 10; 2049, 36 doi:10.3390/antiox11102049 (međunarodna recenzija, pregledni rad, znanstveni)
Tadijan, A., Vlašić, I., Vlainić, J., Đikić, D., Oršolić, N. & Jazvinšćak Jembrek, M. (2022) Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions. Antioxidants, 11 (10), 2049, 36 doi:10.3390/antiox11102049.
@article{article, author = {Tadijan, Ana and Vla\v{s}i\'{c}, Ignacija and Vlaini\'{c}, Josipa and \DJiki\'{c}, Domagoj and Or\v{s}oli\'{c}, Nada and Jazvin\v{s}\'{c}ak Jembrek, Maja}, year = {2022}, pages = {36}, DOI = {10.3390/antiox11102049}, chapter = {2049}, keywords = {Cannabinoids, Neuroprotection, Redox-sensitive signalling pathways, Oxidative stress, Neuroinflammation}, journal = {Antioxidants}, doi = {10.3390/antiox11102049}, volume = {11}, number = {10}, issn = {2076-3921}, title = {Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions}, keyword = {Cannabinoids, Neuroprotection, Redox-sensitive signalling pathways, Oxidative stress, Neuroinflammation}, chapternumber = {2049} }
@article{article, author = {Tadijan, Ana and Vla\v{s}i\'{c}, Ignacija and Vlaini\'{c}, Josipa and \DJiki\'{c}, Domagoj and Or\v{s}oli\'{c}, Nada and Jazvin\v{s}\'{c}ak Jembrek, Maja}, year = {2022}, pages = {36}, DOI = {10.3390/antiox11102049}, chapter = {2049}, keywords = {Cannabinoids, Neuroprotection, Redox-sensitive signalling pathways, Oxidative stress, Neuroinflammation}, journal = {Antioxidants}, doi = {10.3390/antiox11102049}, volume = {11}, number = {10}, issn = {2076-3921}, title = {Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions}, keyword = {Cannabinoids, Neuroprotection, Redox-sensitive signalling pathways, Oxidative stress, Neuroinflammation}, chapternumber = {2049} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





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