engleski

In vivo genotoxicity of ground ivy (Glechoma hederacea L.) and effect on hematological and biochemical blood parameters of rat

Ground ivy (Glechoma hederacea L.), a member of the Lamiacea family, has been used in folk medicine for generations. The aim of the present study was to evaluate in vivo genotoxicity of the water extract of ground ivy and to determine whether there was an effect on hematological and biochemical parameters of blood. The experiment involved 12 Sprague Dawley rats, divided into 4 groups – 2 control groups (female and male) and 2 experimental groups (female and male) which were treated per os with ground ivy extract at a dose of 200 mg of freeze-dried extract per kg of rat for 14 days. The care and use of the experimental animals were in accordance with Croatian animal welfare laws and guidelines. All animals survived the experiments and their white blood, liver and kidney cells were subjected to alkaline comet assay in which tail length and intensity of DNA were determined. According to the obtained results there were no evidence of genotoxic activity after exposure to the ground ivy extract. The detected hematological and biochemical blood parameters did not indicate any adverse effect of the ground ivy extract.

ground ivy ; genotoxicity ; hematological and biochemical blood parameters

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