Reduced plasma BDNF concentration and cognitive decline in veterans with PTSD (CROSBI ID 316336)
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Podaci o odgovornosti
Domitrović Spudić, Sandra ; Nikolac Perković, Matea ; Uzun, Suzana ; Nedić Erjavec, Gordana ; Kozumplik, Oliver ; Švob Štrac, Dubravka ; Mimica, Ninoslav ; Pivac, Nela
engleski
Reduced plasma BDNF concentration and cognitive decline in veterans with PTSD
Post-traumatic stress disorder (PTSD) is a trauma and stress related disorder frequently associated with cognitive decline. War veterans with PTSD have a higher risk of developing dementia than healthy subjects. Brain derived neurotrophic factor (BDNF) is an important protein that modulates plasticity, memory consolidation and cognitive processes. Lower circulating BDNF levels were related to memory impairment and cognitive deterioration. The aim of this study was to evaluate cognitive deterioration and plasma BDNF concentration in 120 veterans with combat related PTSD, 120 healthy controls, 47 subjects with mild cognitive impairment (MCI) and 76 patients with Alzheimer's disease (AD), and to assess if plasma BDNF concentration might be used as biomarker of cognitive deterioration. Veterans with PTSD had significantly decreased plasma BDNF concentration and worse cognitive performances (assessed using the Mini Mental State Examination, Clock Drawing test and Montreal Cognitive Assessment scores/categories) than healthy subjects, and similarly reduced plasma BDNF and cognitive decline as MCI subjects. Reduced plasma BDNF was found in cognitively impaired subjects. These results suggest that veterans with PTSD should be closely monitored in order to early detect and predict cognitive worsening and promote interventions that might help restore blood BDNF levels and cognitive functions.
Alzheimer's disease ; Brain-derived neurotrophic factor ; Cognition ; Mild cognitive impairment ; Post-traumatic stress disorder ; Veterans
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Podaci o izdanju
316
2022.
114772
10
objavljeno
0165-1781
1872-7123
10.1016/j.psychres.2022.114772
Povezanost rada
Temeljne medicinske znanosti