engleski

SP308ASSOCIATION OF HIGH DENSITY LIPOPROTEINS WITH ESTIMATED GLOMERULAR FILTRATION RATE IN PARTICIPANTS WITH INTERMEDIATE AND HIGH RISK OF CARDIOVASCULAR DISEASE

Introduction and Aims: Recent studies show that reduced kidney function is independently associated with low concentrations of high-density lipoprotein (HDL) in patients with end-stage renal disease (ESRD), those on hemodialysis, and those with stage 3-5 chronic kidney disease (CKD). However there are no data showing the relationship between HDL levels and kidney function in populations with intermediate or high total risk of cardiovascular disease. The aim of this study was to investigate the relationship between HDL levels and the estimated glomerular filtration rate (eGFR) in the context of other predictors in patients with intermediate and high total risk of cardiovascular disease calculated by Framingham risk score (FRS). Methods: We enrolled a convenience sample of 187 consecutive patients admitted to the Cardiology Department at the Split University Hospital with FRS≤10, with intermediate and high total risk of cardiovascular disease (defined as estimated FRS>10%). We assessed the association of HDL and eGFR in three groups [based on eGFR as group 1 (<60 ml/min/1.73m2), group 2 (60-90 ml/min/1.73m2) and group 3 (≥90 ml/min/1.73m2)]. Also we assessed this association after adjusting in three models: model 1 (age and gender), model 2 (model 1 plus smoking status, hs-CRP and diabetes mellitus) and model 3 (model 2 plus overweight and obesity, hypertension, hypercholesteronemia, hypertriglyceridemia and family history of CVD). We recorded anthropometric, demographic, laboratory parameters and medications used before hospitalization. Results: In multiple linear regression, correlation was significant (β=0.189, r=0.193, P=0.025) and in multinomial regression, the association between HDL and eGFR was significant for model 1 (B=-3, P=0.002, OR=0.05, CI=0.007- 0.331), model 2 (B=-2.97, P=0.006, OR=0.052, CI=0.006-0.428) and model 3 (B=-3.62, P=0.006, OR=0.27, CI=0.002-0.354). Conclusions: Our study showed that HDL was significantly lower in patients with lower eGFR and that HDL was independently of other predictors associated with eGFR.

heart disease risk factors, high density lipoproteinsglomerular filtration rate, estimated

nije evidentirano