To give or not to give? A critical appraisal of a clinical trial on radioiodine treatment (CROSBI ID 316093)
Prilog u časopisu | uvodnik
Podaci o odgovornosti
Tuncel, Murat ; Vrachimis, Alexis ; Campenni, Alfredo ; de Keizer, Bart ; Verburg, Frederik A. ; Kreissl, Michael C. ; Ovcaricek, Petra Petranovic ; Geliashvili, Tamara ; Giovanella, Luca
engleski
To give or not to give? A critical appraisal of a clinical trial on radioiodine treatment
Recently, Leboulleux et al. published the results of the ESTIMABL 2 trial [1]. It is an open-label, randomised, phase III trial using a noninferiority comparison design. In this study, included patients were at the lowest-risk end of the low-risk spectrum of diferentiated thyroid cancer (DTC) treated with total thyroidectomy with or without lymph node dissection. Patients were randomised to receive low-dose postoperative radioiodine therapy (RAI) with 1.1 GBq in one group and follow-up without RAI in the second group. We congratulate the authors for this work, representing one of the few randomised trials available in the feld. However, we would point out some potential limitations that need to be considered before translating these results to generalised clinical recommendations.
thyroid cancer, radioiodine
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Podaci o izdanju
49 (10)
2022.
3316-3319
objavljeno
1619-7070
1619-7089
10.1007/s00259-022-05841-6
Povezanost rada
Kliničke medicinske znanosti