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Methotrexate-induced toxic effects and the ameliorating effects of astaxanthin on genitourinary tissues in a female rat model

With great interest, we read the article by Gunyeli et al., which investigated the detrimental effects of methotrexate and the potential protective effects of astaxanthin on urogenital tissues (ovary, fallopian tube, uterus, cervix, vagina, urethra). It is an indisputable fact that methotrexate causes oxidative stress and increases the production of pro-inflammatory mediators. On the other hand, as we have seen in our laboratory, astaxanthin shows excellent anti-inflammatory, immunomodulatory and antioxidant effects. We would like to commend the authors for investigating the effect of this powerful antioxidant on the detrimental effects of methotrexate through a multimodal approach (biochemical, histopathological, immunohistochemical). Whether astaxanthin, in the future, will find its place in terms of protecting the reproductive health of women undergoing cancer treatment remains to be seen. It will certainly require more comprehensive human studies in the future, but there are still many issues that need to be explored in animal models.

methotrexate ; astaxanthin ; urogenital tissues ; oxidative stress ; antioxidant

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