Do the myelin basic protein and phosphatidylcholine lipids like to dance together? (CROSBI ID 726717)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Maleš, Petra ; Brkljača, Zlatko ; Bakarić, Danijela
engleski
Do the myelin basic protein and phosphatidylcholine lipids like to dance together?
Myelin is a multilayer membrane tightly wrapped around the axon of neurons, allowing efficient transmission of neural impulses. Slight changes in distributions of lipids in myelin membranes affect their adhesive properties, as well as their bonding with myelin basic protein (MBP), one of the most important myelin-associated proteins. With its high content of positively charged residues, unstructured MBP binds to the anionic lipids of the cytoplasmic leaflets, which causes balance changes between charged lipids and alternations in their lateral organization. All these changes appear in neurodegenerative diseases such as multiple sclerosis (MS) and encephalomyelitis (EAE). It is not yet known what role MBP confinement plays in the efficiency of its adsorption to lipid bilayer made from zwitterionic lipid 1, 2-dipalmitoyl-sn-glycero-3- phosphatidylcholine (DPPC), which constitutes about 40% of myelin lipids.Rather simple spectroscopic and calorimetric techniques such as FTIR spectroscopy, UV/Vis spectrophotometry and DSC can unravel the impact of MBP on phase transition temperatures (Tp, Tm) of DPPC multilamellar and unilamellar liposomes and their structural arrangements. Spectroscopic data will be analyzed with an appropriate chemometric tool.
Phosphatidylcholine ; Liposomes ; MBP ; Lipids
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Podaci o prilogu
147-147.
2022.
objavljeno
Podaci o matičnoj publikaciji
Schneider, Petra
Zagreb: Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu
978-953-6076-93-2
Podaci o skupu
6. Simpozij studenata doktorskih studija PMF-a = 6th Faculty of Science PhD Student Symposium
poster
23.05.2022-24.05.2022
Zagreb, Hrvatska