engleski

Bioelectronic interfaces by PVD of semiconducting organic pigments

Effective and localized, minimally invasive, and physiologically stable wireless electro-stimulation capability would present a valuable tool both in research, as well as in the development of bioelectronic therapies, neural prostheses such as artificial retinas, artificial limbs, auditory prostheses, and brain-machine interfaces. High quality thin films of semiconducting organic pigments can easily be deposited by thermal vacuum evaporation. Such films have shown excellent stability in aqueous environment, either in form of single thin films or as a part of functional devices, such as transistors and photodiodes. We will discuss a family of self-contained photo-capacitive devices for effective wireless bioelectronic stimulation based on a bilayer of organic pigments, metal-free phtylocyanine (H2PC) and N, N’-dimethyl perylenetetracarboxylic diimide (PTCDI) as the active materials - organic electrolytic photocapacitors (OEPC). OEPC devices have demonstrated effective, chronic and localized in-vivo wireless peripheral nerve electric stimulation [1]. We will show how spatial structuring of the OEPC’s affects their optoelectronic [2] and bioelectronic properties, demonstrated by the results of the FEM numerical modelling and measurements of spatial transductive extracellular electric potential field maps. Acknowledgements This work has been supported by Croatian Science Foundation under the project UIP-2019-04-1753. We acknowledge the support of project CeNIKS co-financed by the Croatian Government and the European Union through the European Regional Development Fund - Competitiveness and Cohesion Operational Programme (Grant No. KK.01.1.1.02.0013), and the QuantiXLie Center of Excellence, a project co-financed by the Croatian Government and European Union through the European Regional Development Fund - the Competitiveness and Cohesion Operational Programme (Grant KK.01.1.1.01.0004). Financial support by the Center of Excellence for Advanced Materials and Sensors, Croatia, is gratefully acknowledged. References [1] Silverå Ejneby, M., Jakešová, M., Ferrero, J.J. et al. Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor. Nat Biomed Eng (2021). https://doi.org/10.1038/s41551-021-00817-7 [2] Marta Nikić, Aleksandar Opančar, Florian Hartmann, Ludovico Migliaccio, Marie Jakešová, Eric Daniel Głowacki and Vedran Đerek, Micropyramid structured photo capacitive interfaces, Nanotechnology (2022), Volume 33, Number 24. https://doi.org/10.1088/1361-6528/ac5927

bioelectronic interfaces, PVD, organic pigments, thin films

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