engleski

An eco-friendly route for the synthesis of coumarin based triazole derivatives

Coumarins and their derivatives have attracted considerable attention due to their extensively biological, pharmacological, biochemical and therapeutic activities. Some authors have shown that the combination of coumarin moiety and some nitrogen-containing heterocycles, such as triazoles, contribute to better biological activity in comparison with initial material. Deep eutectic solvents (DESs) are novel generation of “green solvents” that have proven to be a convenient media for many synthetic pathways. They are often described as environmentally friendly and sustainable mixtures of nontoxic and cheap components, whose properties can be adjusted for various applications. Prompted by the above mentioned facts and in continuation of our on-going interest in the development of new green synthetic approaches, the aim of this study was to synthesize coumarin triazole derivatives from 2-[(4-methyl-2- oxo-2H-chromen-7yl)oxy]acetohydrazide and different isocyanates utilizing ChCl-based DES as a reaction media. In first step, we obtained semicarbazides, which were subjected to cyclization in 2% sodium hydroxide solution under reflux to obtain final product. Our method is more convenient than conventional ones, providing high product yields and cleaner reaction paths.

deep eutectic solvents ; coumarin ; triazole

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