Napredna pretraga

Pregled bibliografske jedinice broj: 122745

Products of Advanced Glycation in Patients with Type 2 Diabetes and Vascular Disease


Turk, Zdenka; Šesto, Mihajlo; Skodlar, Jasna; Ferenčak, Goran; Pokupec, Rajko; Turk, Nikša; Stavljenić-Rukavina Ana
Products of Advanced Glycation in Patients with Type 2 Diabetes and Vascular Disease // Annals of clinical biochemistry, 40 (2003), 5; 552-559 (međunarodna recenzija, članak, znanstveni)


Naslov
Products of Advanced Glycation in Patients with Type 2 Diabetes and Vascular Disease

Autori
Turk, Zdenka ; Šesto, Mihajlo ; Skodlar, Jasna ; Ferenčak, Goran ; Pokupec, Rajko ; Turk, Nikša ; Stavljenić-Rukavina Ana

Izvornik
Annals of clinical biochemistry (0004-5632) 40 (2003), 5; 552-559

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Coronary artery disease; Diabetes; Advanced glycation; Immune complex

Sažetak
Background. Nonenzymatic glycation leading to advanced glycation endproduct (AGE) formation is thought to contribute to vascular pathology. In the present study, AGEs and anti-AGE antibodies in free and immune complex bound form were assayed in serum of diabetic (n=69) and nondiabetic (n=78) patients with coronary artery disease (CAD), and in control subjects (n=47) free from vascular disease. Methods. Blocking ELISA was used to test immunoreactivity against AGE epitope(s), and competitive ELISA to measure total AGE content. Results. Anti-AGE immunoreactivity was significantly (p=0.045) higher in diabetic than in control subjects. Although wide range of anti-AGE antibody titre was observed in nondiabetic CAD patients, there was no significant difference from control subjects. Both diabetic and nondiabetic CAD patients had a higher concentration of circulating immune complexes containing AGE moiety as antigen than control subjects (DMCAD vs C: p=0.041 ; CAD vs C: p=0.047). Study patients showed positive correlation between serum AGE and AGE-immune complexes (DM: r=0.29, p=0.014 ; CAD: r=0.26, p=0.019), whereas no such correlation was recorded in controls (r=0.08, p=0.89). Conclusion. To our knowledge, this is the first study demonstrating increased AGE- immune complexes in patients with CAD, either with or without diabetes, suggesting that AGE- immune complexes might be involved in the atherosclerotic process, either as the result of it or as part of the pathophysiologic process.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
0045003

Ustanove
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE