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Evaluation of Antioxidant Potential of Phenolic Compounds Present in Bitter Aloe, Aloe ferox Mill.

Native to southern Africa, bitter aloe (Aloe ferox Mill.) has long been used in traditional medicine. Leaves of bitter aloe are very rich in phytonutrients that exhibit a wide range of health benefitial activities, such as antibacterial, antiviral, antifungal, antidiabetic, anti- inflammatory and immunomodulatory activity [1-3]. Extracts of black elderberry have also shown antioxidant capacity [4]. The aim of this work was to evaluate the antioxidant potential of selected phytoactive compounds present in bitter aloe leaves (flavonoids and phenolic acids) in silico using density-functional theory. The focus was on thermodynamics and studied mechanisms underlying antioxidant activity were hydrogen atom transfer and sequential proton loss electron transfer. Obtained results indicate that studied compounds possess free radical scavenging potency and are able of deactivating various free radicals. Obtained results indicate second hydrogen atom transfer and second sequential proton loss electron transfer processes as less energy demanding than the first ones.

antioxidant activity ; aloe ; flavonoids ; phenolic acids ; DFT

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