engleski

EFFECT OF PENTADECAPEPTIDE BPC 157 ON APICAL PERIODONTITIS CAUSED BY PULP EXPOSURE IN RATS

Introduction: Apical periodontitis is one of the most common inflammatory conditions of the teeth. Despite the frequent failure of mechanical cleaning as the gold standard, there is still no alternative therapy that would reduce the damage caused by the opening of the pulp and preserve the tooth. The pentadecapeptide BPC 157 has shown great healing potential in various animal studies in many experimental models to date. This study aimed to analyze the effect of BPC 157 on a model of apical periodontitis. Materials and methods: Trepanation of the rat's first right maxillary molar was performed on the mesial side of the tooth occlusal surface. The treated groups in the therapy received BPC 157 (10ng/kg or 10µg/kg) per os, while the control group drank water during the experiment. Saliva samples and swabs of the oral cavity were collected for microbiological analysis. The damaged tooth and the surrounding tissue were analyzed histologically and molecularly, while the whole experiment was monitored macroscopically and radiologically. Results: Macroscopic observation showed that the remaining coronal part of the tooth tissue around the trepanation opening is more prone to cracking in the non-treated group. Microbiological analysis showed the same count of colonies and bacterial species in all rats. The area of radiographic periapical bone loss and furcation defect was significantly smaller in rats that were taken BPC 157. This was also confirmed by the histological analysis. Conclusion: This positive effect of BPC 157 opens up opportunities for further research and a novel approach to apical periodontitis treatment.

apical periodontitis, BPC 157

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