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Pregled bibliografske jedinice broj: 1225457

Synthesis and characterization of novel hibride carbamates


Spahić, Zlatan; Martinko, Alen; Hrenar, Tomica; Primožič, Ines
Synthesis and characterization of novel hibride carbamates // Skup: 27. hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem: Knjiga sažetaka / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna (ur.).
Zagreb: Croatian Chemical Society, 2021. str. 270-270 (poster, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 1225457 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis and characterization of novel hibride carbamates

Autori
Spahić, Zlatan ; Martinko, Alen ; Hrenar, Tomica ; Primožič, Ines

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Skup: 27. hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem: Knjiga sažetaka / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Zagreb : Croatian Chemical Society, 2021, 270-270

Skup
Skup: 27. hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Synthesis ; N-benzylimidazole-2-aldoxime carbamates ; stability in aqueous solutions

Sažetak
Oximes and carbamates have a wide spectrum of bioactivities. Some oximes are considered as powerful reactivators of phosphorylated cholinesterase (antidotes for organophosphorus poisoning), [1] while some carbamates are used for inhibition of cholinesterases (protection of enzyme from phosphorylation).[2] Therefore, novel hybrid oxime carbamates have been designed to serve as carbamoylating agents (protection of enzyme) as well as oxime reactivators upon reaction. A series of N-benzylimidazole-2-aldoxime carbamates have been prepared. N-alkylation of commercially available imidazole was carried out with benzyl bromide in THF with sodium hydride as a base. N-benzylimidazole was converted to 2-carbaldehyde derivative by the reaction with n-butyllithium and DMF.[3] N-benzylimidazole-2-aldoximes were synthesized using hydroxylamine hydrochloride in solution and without solvent in mechanochemical reactions.[4] In order to synthesize desired oxime carbamates appropriate carbamoyl chlorides and isocyanates were used. Structures of compounds were deduced from FTIR, ATR, one- and twodimensional NMR spectra. Stability of compounds in aqueous solutions and in organic solvents was determined.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-3775 - Aktivnošću i in silico usmjeren dizajn malih bioaktivnih molekula (ADESIRE) (Hrenar, Tomica, HRZZ - 2016-06) ( CroRIS)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Ines Primožič (autor)

Avatar Url Zlatan Spahić (autor)

Avatar Url Tomica Hrenar (autor)


Citiraj ovu publikaciju:

Spahić, Zlatan; Martinko, Alen; Hrenar, Tomica; Primožič, Ines
Synthesis and characterization of novel hibride carbamates // Skup: 27. hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem: Knjiga sažetaka / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna (ur.).
Zagreb: Croatian Chemical Society, 2021. str. 270-270 (poster, domaća recenzija, sažetak, znanstveni)
Spahić, Z., Martinko, A., Hrenar, T. & Primožič, I. (2021) Synthesis and characterization of novel hibride carbamates. U: Marković, D., Meštrović, E., Namjesnik, D. & Tomašić, V. (ur.)Skup: 27. hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem: Knjiga sažetaka.
@article{article, author = {Spahi\'{c}, Zlatan and Martinko, Alen and Hrenar, Tomica and Primo\v{z}i\v{c}, Ines}, year = {2021}, pages = {270-270}, keywords = {Synthesis, N-benzylimidazole-2-aldoxime carbamates, stability in aqueous solutions}, title = {Synthesis and characterization of novel hibride carbamates}, keyword = {Synthesis, N-benzylimidazole-2-aldoxime carbamates, stability in aqueous solutions}, publisher = {Croatian Chemical Society}, publisherplace = {Veli Lo\v{s}inj, Hrvatska} }
@article{article, author = {Spahi\'{c}, Zlatan and Martinko, Alen and Hrenar, Tomica and Primo\v{z}i\v{c}, Ines}, year = {2021}, pages = {270-270}, keywords = {Synthesis, N-benzylimidazole-2-aldoxime carbamates, stability in aqueous solutions}, title = {Synthesis and characterization of novel hibride carbamates}, keyword = {Synthesis, N-benzylimidazole-2-aldoxime carbamates, stability in aqueous solutions}, publisher = {Croatian Chemical Society}, publisherplace = {Veli Lo\v{s}inj, Hrvatska} }




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