Synthesis and characterization of novel hibride carbamates (CROSBI ID 725839)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Spahić, Zlatan ; Martinko, Alen ; Hrenar, Tomica ; Primožič, Ines
engleski
Synthesis and characterization of novel hibride carbamates
Oximes and carbamates have a wide spectrum of bioactivities. Some oximes are considered as powerful reactivators of phosphorylated cholinesterase (antidotes for organophosphorus poisoning), [1] while some carbamates are used for inhibition of cholinesterases (protection of enzyme from phosphorylation).[2] Therefore, novel hybrid oxime carbamates have been designed to serve as carbamoylating agents (protection of enzyme) as well as oxime reactivators upon reaction. A series of N-benzylimidazole-2-aldoxime carbamates have been prepared. N-alkylation of commercially available imidazole was carried out with benzyl bromide in THF with sodium hydride as a base. N-benzylimidazole was converted to 2-carbaldehyde derivative by the reaction with n-butyllithium and DMF.[3] N-benzylimidazole-2-aldoximes were synthesized using hydroxylamine hydrochloride in solution and without solvent in mechanochemical reactions.[4] In order to synthesize desired oxime carbamates appropriate carbamoyl chlorides and isocyanates were used. Structures of compounds were deduced from FTIR, ATR, one- and twodimensional NMR spectra. Stability of compounds in aqueous solutions and in organic solvents was determined.
Synthesis ; N-benzylimidazole-2-aldoxime carbamates ; stability in aqueous solutions
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Podaci o prilogu
270-270.
2021.
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objavljeno
Podaci o matičnoj publikaciji
Skup: 27. hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem: Knjiga sažetaka
Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna
Zagreb: Hrvatsko kemijsko društvo
Podaci o skupu
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)
poster
05.10.2021-08.10.2021
Veli Lošinj, Hrvatska