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Zagreb 2016 classification of cervical cytology findings – modification of Zagreb 2002 and NCI Bethesda System 2014 classifications

The objective of the Zagreb 2016 classification as the third modification of the unique classification of cervical cytology findings based on the previous Zagreb 2002 and the latest Bethesda 2014 classifications is standardization of cervical cytology findings for the whole Croatia, according to the latest concepts on the biologic behavior of cervical cancer and its precursors. Besides cytomorphological lesions, Zagreb 2016 includes recommendations for diagnostic therapeutic procedures in line with the international recommendations and the experience of Croatian cytologists and gynecologists. It was presented and accepted by Croatian clinical cytologists at the Croatian Society of Clinical Cytology Convention held on December 12, 2016 in Zagreb. The main modifications relative to the Zagreb 2002 classification refer to the following: classification of ‘koilocytosis’, i.e. cytomorphological lesions associated with human papillomavirus, into the category of low-grade squamous intraepithelial lesions (LSIL) ; classification of ‘atypical glandular cells – probably reactive lesions’ into the category of non-neoplastic lesions ; and the introduction of ‘atypical glandular cells – not othervise specified’ (AGC-NOS) into the category of abnormal glandular cells. In addition, the finding of endometrial cells in women aged ≥45 and absence of the transformation zone elements is highlighted.

classifi cation of cervical cytologic fi ndings, Pap test

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