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Synthesis of quinazolinone derivatives using selected green chemistry methods and their potential antibacterial activity

One of the main advantages of green chemistry is the tendency to develop procedures and techniques with low environmental impact. Deep eutectic solvents (DESs) have become an important part of organic synthesis due to their properties. Different quinazolinones were synthesized in choline chloride: urea (1: 2) DES using microwave-assisted and ultrasound-assisted synthesis. First, optimization was performed to find the appropriate DES, time of reaction and temperature. Starting compounds for the quinazolinone synthesis were differently substituted anthranilic acids, anilines and trimethyl orthoformate. The most appropriate method for synthesis was microwave-assisted synthesis using ethanol as a solvent. The antibacterial activity of quinazolinone derivatives was studied by minimal inhibitory concentration. All derivatives have shown antibacterial activity.

green chemistry; quinazolinone derivatives; deep eutectic solvents; antibacterial activity

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