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Pregled bibliografske jedinice broj: 1224522

Psychiatric Illness or Immune Dysfunction—Brain Perfusion Imaging Providing the Answer in a Case of Anti-NMDAR Encephalitis


Šiško Markoš, Ines; Blažeković, Ivan; Peitl, Vjekoslav; Jukić, Tomislav; Supanc, Višnja; Karlović, Dalibor; Fröbe, Ana.
Psychiatric Illness or Immune Dysfunction—Brain Perfusion Imaging Providing the Answer in a Case of Anti-NMDAR Encephalitis // Diagnostics, 12 (2022), 1-10 doi:10.3390/ diagnostics12102377 (međunarodna recenzija, članak, stručni)


CROSBI ID: 1224522 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Psychiatric Illness or Immune Dysfunction—Brain Perfusion Imaging Providing the Answer in a Case of Anti-NMDAR Encephalitis

Autori
Šiško Markoš, Ines ; Blažeković, Ivan ; Peitl, Vjekoslav ; Jukić, Tomislav ; Supanc, Višnja ; Karlović, Dalibor ; Fröbe, Ana.

Izvornik
Diagnostics (2075-4418) 12 (2022); 1-10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
anti-NMDAR encephalitis ; SPECT ; quantification ; schizophrenia

Sažetak
Background: We investigated the potential use of SPECT quantification in addition to qualitative brain perfusion analysis for the detection of anti-NMDAR encephalitis. The question is how to normalize brain activity to be able to quantitatively detect perfusion patterns. Usually, brain activity is normalized to a structure considered unaffected by the disease. Methods: Brain [99mTc]- HMPAO SPECT was performed as a method to detect brain perfusion patterns. The patterns of abnormal brain perfusion cannot always be reliably and qualitatively assessed when dealing with rare diseases. Recent advances in SPECT quantification using commercial software have enabled more objective and detailed analysis of brain perfusion. The cerebellum and whole brain were used as the normalization structures and were compared with visual analysis. Results: The quantification analysis performed with whole brain normalization confirmed right parietal lobe hypoperfusion while also detecting statistically significant left-to-right perfusion differences between the temporal lobe and thalamus. Whole brain normalization further described bilateral frontal lobe hyperperfusion, predominantly of the left lobe, and was in accordance with visual analysis. Conclusion: SPECT quantitative brain perfusion analysis, using the whole brain as the normalization structure rather than the cerebellum, in this case, improved confidence in the visualdetection of anti-NMDAR encephalitis and provided unexpected solutions to atypical psychiatric dilemmas.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Ustanove:
Stomatološki fakultet, Zagreb,
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Hrvatsko katoličko sveučilište, Zagreb

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi

Citiraj ovu publikaciju:

Šiško Markoš, Ines; Blažeković, Ivan; Peitl, Vjekoslav; Jukić, Tomislav; Supanc, Višnja; Karlović, Dalibor; Fröbe, Ana.
Psychiatric Illness or Immune Dysfunction—Brain Perfusion Imaging Providing the Answer in a Case of Anti-NMDAR Encephalitis // Diagnostics, 12 (2022), 1-10 doi:10.3390/ diagnostics12102377 (međunarodna recenzija, članak, stručni)
Šiško Markoš, I., Blažeković, I., Peitl, V., Jukić, T., Supanc, V., Karlović, D. & Fröbe, A. (2022) Psychiatric Illness or Immune Dysfunction—Brain Perfusion Imaging Providing the Answer in a Case of Anti-NMDAR Encephalitis. Diagnostics, 12, 1-10 doi:10.3390/ diagnostics12102377.
@article{article, author = {\v{S}i\v{s}ko Marko\v{s}, Ines and Bla\v{z}ekovi\'{c}, Ivan and Peitl, Vjekoslav and Juki\'{c}, Tomislav and Supanc, Vi\v{s}nja and Karlovi\'{c}, Dalibor and Fr\"{o}be, Ana.}, year = {2022}, pages = {1-10}, DOI = {10.3390/ diagnostics12102377}, keywords = {anti-NMDAR encephalitis, SPECT, quantification, schizophrenia}, journal = {Diagnostics}, doi = {10.3390/ diagnostics12102377}, volume = {12}, issn = {2075-4418}, title = {Psychiatric Illness or Immune Dysfunction—Brain Perfusion Imaging Providing the Answer in a Case of Anti-NMDAR Encephalitis}, keyword = {anti-NMDAR encephalitis, SPECT, quantification, schizophrenia} }
@article{article, author = {\v{S}i\v{s}ko Marko\v{s}, Ines and Bla\v{z}ekovi\'{c}, Ivan and Peitl, Vjekoslav and Juki\'{c}, Tomislav and Supanc, Vi\v{s}nja and Karlovi\'{c}, Dalibor and Fr\"{o}be, Ana.}, year = {2022}, pages = {1-10}, DOI = {10.3390/ diagnostics12102377}, keywords = {anti-NMDAR encephalitis, SPECT, quantification, schizophrenia}, journal = {Diagnostics}, doi = {10.3390/ diagnostics12102377}, volume = {12}, issn = {2075-4418}, title = {Psychiatric Illness or Immune Dysfunction—Brain Perfusion Imaging Providing the Answer in a Case of Anti-NMDAR Encephalitis}, keyword = {anti-NMDAR encephalitis, SPECT, quantification, schizophrenia} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





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