engleski

Worsening of kidney function following COVID-19

The goal of this paper is quantifying and describing the population of patients affected with a decline in renal function following COVID- 19 in a tertiary care center in Croatia. Materials and methods: This is a retrospective analysis of patients affected with a recent decline in renal function following COVID-19. Data was imported from the Hospital Informatical System (BIS) and charted in a database, with the following parameters: Patient gender, age, BMI, blood pressure, laboratory values, estimation of glomerular filtration rate using the 2021 CKD-EPI formula, time elapsed from positive PCR test for SARS-CoV-2. Patients without a digital record of a positive PCR test were excluded, as well as patients without the necessary laboratory and clinical parameters. Result and conclusion: Among the 190 studied patients with post-COVID symptoms, 12 (6.31%) had a decline in renal function. When compared to patients with other post-COVID manifestations, these patients had stastistically significant lower diastolic blood pressure (median 79 vs 84 mmHg, p = 0.033), higher serum creatinine values (median 113 vs 74.5 umol/L, p < 0.001), lower eGFR (median 46.1 vs 85 mL/min/m^2, p < 0.001) and higher CRP values (median 36 vs 6.1 mg/L, p = 0.033). There was no statistically significant difference in age, systolic blood pressure or time to onset of post-COVID symptoms between the two groups. While the mechanisms through which the SARS-CoV-2 virus causes lasting organ damage are still actively being studied, clinicians are faced with the challenge of recognizing patients affected by the so-called “post-COVID” syndrome. Although much of the focus is still being concentrated on treating the active illness, the numbers displayed in this study (more than 6% of patients with post-COVID being affected with lasting renal damage) direct us towards an approach that appreciates COVID-19 as not only an acute condition, but also a potential instigator of “de-novo” chronic illness.

COVID-19 ; Post-COVID ; Renal Function Impariment

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