Biopharmaceutical properties of mucoadhesive powder platform for donepezil nasal delivery (CROSBI ID 725471)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Perkušić, Mirna ; Nižić Nodilo, Laura ; Jakobušić Brala, Cvijeta ; Pepić, Ivan ; Lovrić, Jasmina ; Hafner, Anita
engleski
Biopharmaceutical properties of mucoadhesive powder platform for donepezil nasal delivery
Background Donepezil hydrochloride (DH) is commonly used for the treatment of symptoms of Alzheimer’s disease as an oral dosage form (1). Nasal DH administration provides the potential for direct and efficient DH delivery to the central nervous system, while reducing its systemic side effects (2). Purpose The aim of this study is to investigate the potential of spray dried DH loaded chitosan/mannitol microspheres for nasal DH delivery by relevant biopharmaceutical in vitro and ex vivo characterisation. Methods DH loaded chitosan/mannitol microspheres were characterised in terms of DH in vitro release profile, ex vivo mucoadhesiveness using porcine nasal mucosa, in vitro biocompatibility with Calu- 3 cells and DH permeability across Calu-3 cell monolayer. DH loaded chitosan microspheres, pure DH powder and/or pure mannitol were used as controls where appropriate. Results Both, chitosan and chitosan/mannitol microspheres provided prolonged DH release in comparison to pure DH powder. DH loaded chitosan/mannitol microspheres showed prominent mucoadhesive properties. Calu-3 cells exposed to microsphere suspensions prepared at chitosan concentration 10– 30 μg/mL retained viability above 90% in relation to negative control. The Papp values of DH from chitosan/mannitol and chitosan microspheres showed 1.16 and 1.30-fold higher DH permeation in relation to DH solution, respectively. Conclusion Formulating DH as chitosan/mannitol microspheres resulted in prolonged drug release, increased mucoadhesiveness and enhanced drug permeation across Calu-3 monolayer. Results on in vitro biocompatibility confirmed the formulation potential for safe and efficient DH nasal delivery.
nasal drug delivery ; spray-dried microparticles ; chitosan ; donepezil ; biopharmaceutical properties
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Podaci o prilogu
20-20.
2022.
objavljeno
Podaci o matičnoj publikaciji
Podaci o skupu
80th FIP World Congress of Pharmacy and Pharmaceutical Sciences (FIP Seville 2022)
poster
18.09.2022-22.09.2022
Sevilla, Španjolska