engleski

Volatiles of Dittrichia viscosa (L.) Greuter – Biological Activities of Essential Oil and Hydrosol

Biologically active compounds from natural sources were studied in a readily available aromatic wild shrub widely distributed in the Mediterranean region, the species Dittrichia viscosa (L.) Greuter (Asteraceae). We investigated a phytochemical profile of D. viscosa by GC-MS and HPLC analysis of the lipophilic fraction (essential oil) and the water fraction (hydrosol). GC-MS analysis identified 1, 8-cineole, caryophyllene oxide, α-terpenyl acetate, and a- muurolol as the major constituents of the essential oil, while in the hydrosol p-menth-1-en- 9-ol, 1, 8-cineole, linalool, cis-sabinene hydrate, and a-muurolol were the major volatile constituents. HPLC analysis identified 3, 4- dihydroxybenzoic acid as the predominant compound among phenolic compounds in the hydrosol composition. The antimicrobial potential of both extracts was evaluated against thirteen opportunistic pathogens associated with common skin and wound infections and emerging food spoilage microorganisms. The antimicrobial activity of the essential oil suggests that the volatiles of D. viscosa could be used as novel antimicrobial agents. The antiproliferative results of D. viscosa are also novel findings that showed promising activity against three cancer cell lines: HeLa (cervical cancer cell line), HCT116 (human colon cancer cell line), and U2OS (human osteosarcoma cell line). The results presented are also the first report of significant antiphytoviral activity of hydrosol against tobacco mosaic virus infection. The results show that D. viscosa is much more than a weed plant, with the potential in crop protection, as a natural disinfectant and natural anticancer agent.

Dittrichia viscosa ; volatiles, antiviral, antimicrobial, anticancer activity

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