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Pregled bibliografske jedinice broj: 1224247

Development of sprayable in situ gelling system for nasal donepezil delivery: Preliminary formulation and deposition studies


Perkušić, Mirna; Nižić Nodilo, Laura; Jakobušić Brala, Cvijeta; Pepić, Ivan; Saršon, Vesna; Safundžić Kučuk, Maša; Zadravec, Dijana; Kalogjera, Livije; Hafner, Anita
Development of sprayable in situ gelling system for nasal donepezil delivery: Preliminary formulation and deposition studies // 80th FIP World Congress of Pharmacy and Pharmaceutical Sciences
Sevilla, Španjolska, 2022. str. 22-22 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1224247 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Development of sprayable in situ gelling system for nasal donepezil delivery: Preliminary formulation and deposition studies

Autori
Perkušić, Mirna ; Nižić Nodilo, Laura ; Jakobušić Brala, Cvijeta ; Pepić, Ivan ; Saršon, Vesna ; Safundžić Kučuk, Maša ; Zadravec, Dijana ; Kalogjera, Livije ; Hafner, Anita

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
80th FIP World Congress of Pharmacy and Pharmaceutical Sciences

Mjesto i datum
Sevilla, Španjolska, 18.09.2022. - 22.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
donepezil ; nasal drug delivery ; in situ gel ; chitosan ; 3D printed nasal cast

Sažetak
BACKGROUND Due to disadvantages of oral administration of anti-dementia drug donepezil, nose-to-brain delivery attracts much attention as more efficient and safe route of administration (1). Nasal drug administration enables delivery to the central nervous system via olfactory nerve that innervates olfactory region of the nasal cavity. To ensure targeted delivery to the olfactory region, nasal deposition studies should be implemented in early phase of formulation development (2). PURPOSE The purpose of this study is to set the basis for the development of sprayable in situ gelling donepezil delivery system and to recognise the formulation and administration parameters with the highest impact on nasal deposition pattern. METHODS Thermosensitive chitosan (CS) based formulations for donepezil nose-to-brain delivery were prepared using CS and β-glycerophosphate as the gelling agent. In situ gelling systems were characterised in terms of rheological properties, droplet size distribution (DSD), spray cone angle (SCA) and nasal deposition pattern by using a representative 3D printed nasal cast. RESULTS Thermosensitive CS based in situ gelling donepezil formulations have been successfully prepared. Formulations showed suitable rheological characteristics and thermogelling properties. Under formulation and administration parameters employed, appropriate window of DSD and SCA was reached, resulting in targeted deposition in the olfactory region. CONCLUSION Preliminary studies revealed crucial formulation and administration parameters that resulted in suitable rheological properties and aerosol performance that paved the way for targeted nose- to-brain delivery.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekti:
HRZZ-UIP-2017-05-4592 - Optimiranje depozicije raspršenih in situ gelirajućih i praškastih terapijskih sustava u nosnoj šupljini (OptiNasalSpray) (Hafner, Anita, HRZZ - 2017-05) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
KBC "Sestre Milosrdnice"


Citiraj ovu publikaciju:

Perkušić, Mirna; Nižić Nodilo, Laura; Jakobušić Brala, Cvijeta; Pepić, Ivan; Saršon, Vesna; Safundžić Kučuk, Maša; Zadravec, Dijana; Kalogjera, Livije; Hafner, Anita
Development of sprayable in situ gelling system for nasal donepezil delivery: Preliminary formulation and deposition studies // 80th FIP World Congress of Pharmacy and Pharmaceutical Sciences
Sevilla, Španjolska, 2022. str. 22-22 (poster, međunarodna recenzija, sažetak, znanstveni)
Perkušić, M., Nižić Nodilo, L., Jakobušić Brala, C., Pepić, I., Saršon, V., Safundžić Kučuk, M., Zadravec, D., Kalogjera, L. & Hafner, A. (2022) Development of sprayable in situ gelling system for nasal donepezil delivery: Preliminary formulation and deposition studies. U: 80th FIP World Congress of Pharmacy and Pharmaceutical Sciences.
@article{article, author = {Perku\v{s}i\'{c}, Mirna and Ni\v{z}i\'{c} Nodilo, Laura and Jakobu\v{s}i\'{c} Brala, Cvijeta and Pepi\'{c}, Ivan and Sar\v{s}on, Vesna and Safund\v{z}i\'{c} Ku\v{c}uk, Ma\v{s}a and Zadravec, Dijana and Kalogjera, Livije and Hafner, Anita}, year = {2022}, pages = {22-22}, keywords = {donepezil, nasal drug delivery, in situ gel, chitosan, 3D printed nasal cast}, title = {Development of sprayable in situ gelling system for nasal donepezil delivery: Preliminary formulation and deposition studies}, keyword = {donepezil, nasal drug delivery, in situ gel, chitosan, 3D printed nasal cast}, publisherplace = {Sevilla, \v{S}panjolska} }
@article{article, author = {Perku\v{s}i\'{c}, Mirna and Ni\v{z}i\'{c} Nodilo, Laura and Jakobu\v{s}i\'{c} Brala, Cvijeta and Pepi\'{c}, Ivan and Sar\v{s}on, Vesna and Safund\v{z}i\'{c} Ku\v{c}uk, Ma\v{s}a and Zadravec, Dijana and Kalogjera, Livije and Hafner, Anita}, year = {2022}, pages = {22-22}, keywords = {donepezil, nasal drug delivery, in situ gel, chitosan, 3D printed nasal cast}, title = {Development of sprayable in situ gelling system for nasal donepezil delivery: Preliminary formulation and deposition studies}, keyword = {donepezil, nasal drug delivery, in situ gel, chitosan, 3D printed nasal cast}, publisherplace = {Sevilla, \v{S}panjolska} }




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