Serum and urine profiling by high-throughput TMT- based proteomics for the investigation of renal dysfunction in canine babesiosis (CROSBI ID 315339)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Bilić, Petra ; Horvatić, Anita ; Kuleš, Josipa ; Gelemanović, Andrea ; Beer Ljubić, Blanka ; Mũnoz- Prieto, Alberto ; Gotić, Jelena ; Žubčić, Damir ; Barić Rafaj, Renata ; Mrljak, Vladimir
engleski
Serum and urine profiling by high-throughput TMT- based proteomics for the investigation of renal dysfunction in canine babesiosis
Canine babesiosis is a tick-borne disease caused by Babesia canis, with acute kidney injury as one of the common complications. In the study 8 healthy control dogs and 22 dogs with naturally occurring babesiosis were enrolled, with the aim to analyse differences in serum and urinary proteomes between healthy dogs and dogs with different degree of renal dysfunction in babesiosis using a label-based high-throughput quantitative proteomic approach. In serum, 58 proteins were found differentially abundant between healthy controls and groups of dogs with different degrees of renal dysfunction in babesiosis, while in urine there were 259 differentially abundant proteins. In addition, altered biological pathways were detected in the diseased dogs using bioinformatics tools and validation of several candidate biomarkers was performed.
Babesiosis ; Serum ; Urine ; Quantitative proteomics ; Tandem mass tag ; Kidney dysfunction
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
270
2023.
104735
12
objavljeno
1874-3919
1876-7737
10.1016/j.jprot.2022.104735