engleski

Uric acid as a biomarker in nutritional metabolism: a focus on diabetes

Uric acid (UA) is a weak acid generated from the purine metabolism. UA exists in serum as urate, the salt of uric acid, and vary significantly with diet. The balance of UA levels is driven by ingestion of purines, endocrine production and excretion. Ingestion of animal proteins is most important factor leading to hyperuricemia. Hyperuricemia in humans increases the risk of gout, nephrolithiasis, and other comorbidities related to high UA levels. Recently, hyperuricemia is proposed to be a biomarker in a several other renal, metabolic, and cardiovascular disorders and to play an important role in vascular inflammation and atherosclerosis. Clinical management of hyperuricemia includes controlling food intake and therapy with uricosuric agent. In clinical practice, targeting lower UA levels may help in reducing the risk of development and harmful effects of nowadays frequent metabolic disorders associated with obesity, metabolic syndrome and type 2 diabetes mellitus.

uric acid ; hyperuricemia ; purine ; diet ; gout ; nephrolithiasis ; xanthine oxidase ; metabolic syndrome ; type 2 diabetes ; cardiovascular disease ; inflammation ; nutrition

nije evidentirano