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Chronic Endothelial Dysfunction after COVID-19 Infection Shown by Transcranial Color-Coded Doppler: A Cross-Sectional Study (CROSBI ID 315245)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Marčić, Marino ; Marčić, Ljiljana ; Lovrić Kojundžić, Sanja ; Marinović Guić, Maja ; Marčić, Barbara ; Čaljkušić, Krešimir Chronic Endothelial Dysfunction after COVID-19 Infection Shown by Transcranial Color-Coded Doppler: A Cross-Sectional Study // Biomedicines, (2022), 10/2550; 1-14. doi: 10.3390/biomedicines10102550

Podaci o odgovornosti

Marčić, Marino ; Marčić, Ljiljana ; Lovrić Kojundžić, Sanja ; Marinović Guić, Maja ; Marčić, Barbara ; Čaljkušić, Krešimir

engleski

Chronic Endothelial Dysfunction after COVID-19 Infection Shown by Transcranial Color-Coded Doppler: A Cross-Sectional Study

In addition to respiratory symptoms, COVID-19 often causes damage to many other organs, especially in severe forms of the disease. Long- term consequences after COVID-19 are common and often have neurological symptoms. Cerebral vasoreactivity may be impaired after acute COVID- 19 and in our study, we wanted to show how constant and reversible are the changes in brain vasoreactivity after infection. This cross- sectional observational study included 49 patients diagnosed with COVID-19 and mild neurological symptoms 300 days after the onset of the disease. We used a transcranial color-coded Doppler (TCCD) and a breath-holding test (BHT) to examine cerebral vasoreactivity and brain endothelial function. We analyzed the parameters of the flow rate through the middle cerebral artery (MCA): peak systolic velocity (PSV), end-diastolic velocity (EDV), mean velocity (MV), resistance index (RI) and pulsatility index (PI), and we calculated the breath-holding index (BHI). Subjects after COVID-19 infection had lower measured velocity parameters through MCA at rest period and after BHT, lower relative increases of flow velocities after BHT, and lower BHI. We showed that subjects, 300 days after COVID-19, still have impaired cerebral vasoreactivity measured by TCCD and they have chronic endothelial dysfunction.

endothelial dysfunction ; post-acute COVID-19 ; vasoreactivity ; transcranial color-coded Doppler

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Podaci o izdanju

(10/2550)

2022.

1-14

objavljeno

2227-9059

10.3390/biomedicines10102550

Trošak objave rada u otvorenom pristupu

Povezanost rada

Integrativna bioetika (prirodne, tehničke, biomedicina i zdravstvo, biotehničke, društvene, humanističke znanosti), Kliničke medicinske znanosti, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)

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