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DNA Methylome Changes of Muscle- and Neuronal- Related Processes Precede Bladder Cancer Invasiveness

Urinary bladder cancer can be therapeutically controlled until it becomes invasive, thus identifying critical molecular processes preceding and promoting the transition from pre-invasive to invasive tumors is of vital medical importance. Here, we tested epigenomic (DNA methylation) and gene expression profiles in non-invasive and invasive bladder cancers. We found methylation changes in the genes related to muscle and neuronal processes that discriminate between two cancer stages. Our results may open new avenues for early diagnosis of pre-invasive tumors by testing methylation profiles of tumor cells present in patients’ urine or biopsies leading to timely therapeutic measures.

bladder cancer ; DNA methylation ; gene expression ; invasiveness ; muscle contraction ; neuronal system

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