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Boron doxorubicin chitosan scaffolds as dual functional carriers with antitumor efficacy and bone regeneration ability

Biologically compatible scaffolds have been considered as promising platforms for tissue regeneration, drug delivery and tumor treatments. Chitosan-based scaffolds can serve as pH-responsive drug carriers with targeted delivery resulting in less invasive tumor treatments. Going further, development of dual-functional carriers that will provide simultaneous antitumor efficacy and induce tissue regeneration through therapeutic ions can advance current tumor treatments. Here, boric acid-containing crosslinked chitosan scaffolds were prepared as pH-responsive carriers for doxorubicin, a chemotherapy drug used to treat tumors such as osteosarcoma, while simultaneously inducing bone regeneration through therapeutic effect of boron. The encapsulation of boric acid and doxorubicin was confirmed by FTIR and XRD analysis, while doxorubicin release from chitosan-based scaffold was evaluated in phosphate buffers of different pH (6.0 and 7.4) during 24 hours using HPLC method. The obtained scaffolds exhibit a highly porous and interconnected microstructure capable of high drug encapsulation efficiency. Due to chitosan’s polycationic nature, the obtained scaffolds exhibit higher swelling and drug release at lower pH characteristic for tumor microenvironment making them possible candidates for targeted drug delivery. The cytotoxicity of prepared doxorubicin carriers was evaluated on human sarcoma cells at pH 6.0 indicating proposed materials as cytotoxic agents.

chitosan ; hydrogels ; boron ; doxorubicin ; sarcoma

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