The association of serotonin receptor genes polymorphisms with CSF, genetic, and neuropsychological biomarkers of Alzheimer's disease (CROSBI ID 724877)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Babić Leko, Mirjana ; Nikolac Perković, Matea ; Švob Štrac, Dubravka ; Pleić, Nikolina ; Gunjača, Ivana ; Klepac, Nataša ; Borovečki, Fran ; Pivac, Nela ; Zemunik, Tatijana ; Hof, Patrick R. ; Šimić, Goran
engleski
The association of serotonin receptor genes polymorphisms with CSF, genetic, and neuropsychological biomarkers of Alzheimer's disease
Serotonergic receptors are affected in Alzheimer's disease (AD). The overall decrease in the serotonergic transmission is also observed in AD. Previous studies showed the association of polymorphisms in genes for serotonin (5HT) receptors with behavioral and psychological symptoms of dementia (BPSD). In this study, we aimed to test if individuals carrying different genotypes in 5HTR2A rs 6313 (T102C), 5HTR1B rs13212041, 5HTR6 rs1805054 (C267T), and 5HTR2C rs 3813929 (-795C/T) polymorphisms have a higher risk for development of AD. Cerebrospinal fluid (CSF) AD biomarkers, neuropsychological tests, and apolipoprotein E (APOE) haplotype were determined in 115 AD patients and 53 mildly cognitively impaired patients, while 2701 cognitively healthy individuals with determined APOE haplotype were also included. We observed that all four analyzed polymorphisms in genes for 5HT receptors showed an association with either CSF, neuropsychological or genetic biomarkers of AD. Thus, the potential of these polymorphisms as early genetic biomarkers of AD should be further investigated.
Alzheimer's disease ; serotonin receptors ; biomarkers ; genetics ; cerebrospinal fluid
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Podaci o prilogu
61-61.
2022.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Neurologia Croatica. Supplement
Šimić, Goran ; Mimica, Ninoslav
Zagreb: Denona
1331-5196
Podaci o skupu
Croatian congress on Alzheimer's disease (CROCAD-22)
poster
05.10.2022-08.10.2022
Supetar, Hrvatska