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Pregled bibliografske jedinice broj: 122161

Advanced Glycation Endproducts in Various Stages of Proteinuria


Turk, Zdenka; Mornar, Ana; Turk, Nikša; Mrzljak, Vladimir
Advanced Glycation Endproducts in Various Stages of Proteinuria // Abstracts of the ..... ; u: Diabetes & metabolism 29 (2003) (4S), 2003. str. S350-S350 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Advanced Glycation Endproducts in Various Stages of Proteinuria

Autori
Turk, Zdenka ; Mornar, Ana ; Turk, Nikša ; Mrzljak, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the ..... ; u: Diabetes & metabolism 29 (2003) (4S) / - , 2003, S350-S350

Mjesto i datum
,

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Advanced glycation; Proteinuria; Diabetic nephropathy

Sažetak
Nonenzymatic glycation leading to advanced glycation endproduct (AGE) formation is one of the important biochemical pathways involved in the development of long-term complications of diabetes, with a potential role also in diabetic nephropathy. The objective of the present study was to evaluate the relationship between advanced glycation-derived proteins in urine and progression of diabetic nephropathy. AGE-immunoreactivity was measured in 24-h urine collection of diabetic patients with normoalbuminuria (N), microalbuminuria (Mi), macroalbuminuria (Ma), and persistent proteinuria with elevated serum creatinine level (PC). A competitive immunoassay (solid-phase bound AGE-human serum albumin) and polyclonal anti-AGE antibodies were used to monitor AGE excretion. Comparison of urine AGE content among various stages of proteinuria showed significant between-group differences: Mi vs N (p<0.003) and Ma vs Mi (p<0.001). In the group of normoalbuminuric patients, AGE-immunoreactivity was not detected in 50% of samples, whereas in the group of patients with microalbuminuria only 15% of samples were AGE negative. However, there was no statistically significant difference in AGE excretion between the patients with persistent proteinuria and elevated serum creatinine, and those with macroalbuminuria (PC vs Ma, p<0.36). In these two groups of patients in whom highest AGE content in 24-h urine collection was measured, no negative AGE-immunoreactivity was recorded. Multiple regression analysis emphasized significant correlation (r=0.72, p<0.022) between urinary AGE-immunoreactivity and urinary albumin excretion. The results suggested that urinary AGE-immunoreactivity is mainly associated with albumin molecules or minor protein fragments. Since an increased urinary albumin excretion predicts clinical diabetic nephropathy, we consider that determination of AGE-linked albuminuria may be used as a predictive marker for early detection of not only diabetic nephropathy but also of other diabetic complications.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekt / tema
0045003

Ustanove
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac

Profili:

Avatar Url Vladimir Mrzljak (autor)

Avatar Url Ana Mornar Turk (autor)

Avatar Url Nikša Turk (autor)

Avatar Url Zdenka Turk (autor)

Citiraj ovu publikaciju

Turk, Zdenka; Mornar, Ana; Turk, Nikša; Mrzljak, Vladimir
Advanced Glycation Endproducts in Various Stages of Proteinuria // Abstracts of the ..... ; u: Diabetes & metabolism 29 (2003) (4S), 2003. str. S350-S350 (poster, međunarodna recenzija, sažetak, znanstveni)
Turk, Z., Mornar, A., Turk, N. & Mrzljak, V. (2003) Advanced Glycation Endproducts in Various Stages of Proteinuria. U: Abstracts of the ..... ; u: Diabetes & metabolism 29 (2003) (4S).
@article{article, year = {2003}, pages = {S350-S350}, keywords = {Advanced glycation, Proteinuria, Diabetic nephropathy}, title = {Advanced Glycation Endproducts in Various Stages of Proteinuria}, keyword = {Advanced glycation, Proteinuria, Diabetic nephropathy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE