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izvor podataka: crosbi

Satellite DNAs in Health and Disease (CROSBI ID 314881)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Ugarković, Đurđica ; Sermek, Antonio ; Ljubić, Sven ; Feliciello, Isidoro Satellite DNAs in Health and Disease // Genes, 13 (2022), 1154, 15. doi: 10.3390/genes13071154

Podaci o odgovornosti

Ugarković, Đurđica ; Sermek, Antonio ; Ljubić, Sven ; Feliciello, Isidoro

engleski

Satellite DNAs in Health and Disease

Tandemly repeated satellite DNAs are major components of centromeres and pericentromeric heterochromatin which are crucial chromosomal elements responsible for accurate chromosome segregation. Satellite DNAs also contribute to genome evolution and the speciation process and are important for the maintenance of the entire genome inside the nucleus. In addition, there is increasing evidence for active and tightly regulated transcription of satellite DNAs and role for their transcripts in diverse processes. In this review, we focus on recent discoveries related to the regulation of satellite DNA expression and the role of their transcripts either in heterochromatin establishment and centromere function or in gene expression regulation under various biological contexts. We discuss the role of satellite transcripts in the stress response and environmental adaptation as well as consequences of dysregulation of satellite DNA expression in cancer and their potential use as cancer biomarkers.

satellite DNA ; heterochromatin ; satellite RNA ; epigenetics ; heat stress ; cancer ; biomarker

nije evidentirano

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Podaci o izdanju

13

2022.

1154

15

objavljeno

2073-4425

10.3390/genes13071154

Trošak objave rada u otvorenom pristupu

APC

Povezanost rada

Biologija

Poveznice
Indeksiranost