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Pregled bibliografske jedinice broj: 122073

Dendritic overgrowth and alterations in laminar phenotypes of neocortical neurons in the newborn with semilobar holoprosencephaly


Judaš, Miloš; Rašin, Mladen Roko; Krušlin, Božo; Kostović, Krešimir; Jukić, Dražen; Petanjek, Zdravko; Kostović, Ivica
Dendritic overgrowth and alterations in laminar phenotypes of neocortical neurons in the newborn with semilobar holoprosencephaly // Brain & development (Tokyo), 25 (2003), 1; 32-39 (međunarodna recenzija, članak, znanstveni)


Naslov
Dendritic overgrowth and alterations in laminar phenotypes of neocortical neurons in the newborn with semilobar holoprosencephaly

Autori
Judaš, Miloš ; Rašin, Mladen Roko ; Krušlin, Božo ; Kostović, Krešimir ; Jukić, Dražen ; Petanjek, Zdravko ; Kostović, Ivica

Izvornik
Brain & development (Tokyo) (0387-7604) 25 (2003), 1; 32-39

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
del(18p); Golgi impregnacija; stereološka neuromorfometrija; subplate zona
(del(18p9; Rapid Golgi impregnation; 3D-stereological neuromorphometry; acetylcholinesterase histochemistry; subplate zone; holoprosencephaly)

Sažetak
We analyzed neuronal phenotypes and dendritic growth in the newborn with semilobar holoprosencephaly and 18p deletion. We found that the holoprosencephalic neocortex retained its basic six-layered lamination but displayed a number of intralaminar and modular architectonic alterations and contained a mixture of normal and aberrant neuronal phenotypes. The most conspicuous finding was the presence of the pronounced increase in soma size and total basal dendritic length of holoprosencephalic layer III pyramidal neurons in comparison to age-matched control brains. The dramatic (5-fold) dendritic overgrowth observed in associative cortico-cortical pyramidal neurons is probably related to the pronounced diminution of the cortical afferent input.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
0108001
0108115
0108118

Ustanove
Medicinski fakultet, Zagreb

Profili:

Avatar Url Ivica Kostović (autor)

Avatar Url Miloš Judaš (autor)

Avatar Url Božo Krušlin (autor)

Avatar Url Zdravko Petanjek (autor)

Citiraj ovu publikaciju

Judaš, Miloš; Rašin, Mladen Roko; Krušlin, Božo; Kostović, Krešimir; Jukić, Dražen; Petanjek, Zdravko; Kostović, Ivica
Dendritic overgrowth and alterations in laminar phenotypes of neocortical neurons in the newborn with semilobar holoprosencephaly // Brain & development (Tokyo), 25 (2003), 1; 32-39 (međunarodna recenzija, članak, znanstveni)
Judaš, M., Rašin, M., Krušlin, B., Kostović, K., Jukić, D., Petanjek, Z. & Kostović, I. (2003) Dendritic overgrowth and alterations in laminar phenotypes of neocortical neurons in the newborn with semilobar holoprosencephaly. Brain & development (Tokyo), 25 (1), 32-39.
@article{article, year = {2003}, pages = {32-39}, keywords = {del(18p9, Rapid Golgi impregnation, 3D-stereological neuromorphometry, acetylcholinesterase histochemistry, subplate zone, holoprosencephaly}, journal = {Brain and development (Tokyo)}, volume = {25}, number = {1}, issn = {0387-7604}, title = {Dendritic overgrowth and alterations in laminar phenotypes of neocortical neurons in the newborn with semilobar holoprosencephaly}, keyword = {del(18p9, Rapid Golgi impregnation, 3D-stereological neuromorphometry, acetylcholinesterase histochemistry, subplate zone, holoprosencephaly} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE