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Development of carbon paste electrode for the potentiometric determination of acebutolol

Electrodes based on carbon paste are often used in electrochemical measurements due to their good physical and chemical properties.[1] In this work carbon paste electrodes (CPEs) for the potentiometric determination of the acebutolol hydrochloride, cardiovascular drug from the family of beta blockers, were prepared. The design and manufacture of the working electrode body was previously reported.[2] Some of the most frequently tested binders in the last ten years, such as: dibutyl phthalate, bis(2-ethylhexyl)phthalate, paraffin oil, tris(2-ethylhexyl)phosphate, 2-nitrophenyl-octyl-ether and bis(2-ethylhexyl) adipate were used. In order to improve the sensitivity, the CPE were modified by the addition of previously precipitated ion association complexes (IAC) and various ion additives. All measurements were performed in the concentration range of working solutions of acebutolol from 3.16×10−6 M to 3.16×10−3 M in an acetate buffer with a pH value of 5.0. Although this research gave promising results, prepared CPEs showed worse preliminary response characteristics than CPE for acebutolol determination previously reported.[3] In further research, emphasis is going to be placed on the incorporation of different nanomaterials into the paste, especially those made of carbon materials.

carbon paste electrodes, potentiometry, acebutolol

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