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Effects of polystyrene micro- and nanoparticles and their mixtures with pharmaceuticals on modulation of estrogen receptor activity in vitro

Micro- and nanoplastic particles (MNPs) are widely present in different environmental and biological matrices due to the frequent use of plastics and inefficient waste management. MNPs have recently also been found in human blood. One of main concerns for hazardous health effects of MNPs is their potential to adsorb various pollutants. This research is focused on polystyrene MNPs and their mixture with paracetamol and ibuprofen, drugs that have endocrine disrupting activity. Due to their frequent and wide use, they are present in different water bodies, including drinking water, and may easily come in contact with MNPs forming complex mixtures. The aim of our study was to investigate effects of such complex mixtures on modulation of estrogen receptor (ER) activity using in vitro model of human breast tissue.

polystyrene ; microparticles ; nanoparticles ; pharmaceuticals ; mixtures ; estrogen receptor ; in vitro

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