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Pregled bibliografske jedinice broj: 1220172

Gram-negative bacteria as causative agents of ventilator-associated pneumonia and their respective resistance mechanisms


Bandić Pavlović, Daniela; Zah Bogović, Tajana; Žižek, Marta; Bijelan, Luka; Bratić, Vesna; Hrabač, Pero; Slačanac, Domagoj; Mihaljević, Slobodan; Bedenić, Branka
Gram-negative bacteria as causative agents of ventilator-associated pneumonia and their respective resistance mechanisms // Journal of chemotherapy, 32 (2020), 7; 344-358 doi:10.1080/1120009X.2020.1793594 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1220172 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Gram-negative bacteria as causative agents of ventilator-associated pneumonia and their respective resistance mechanisms

Autori
Bandić Pavlović, Daniela ; Zah Bogović, Tajana ; Žižek, Marta ; Bijelan, Luka ; Bratić, Vesna ; Hrabač, Pero ; Slačanac, Domagoj ; Mihaljević, Slobodan ; Bedenić, Branka

Izvornik
Journal of chemotherapy (1120-009X) 32 (2020), 7; 344-358

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Acinetobacter baumannii ; Klebsiella pneumoniae ; Pseudomonas aeruginosa ; Ventilator-associated pneumonia

Sažetak
Ventilator-associated pneumonia (VAP) is a serious and common complication in patients admitted to intensive care unit (ICU) and contributes to mortality. Multidrug Gram-negative bacteria such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae are frequently associated with VAP in ICU. A prospective study was set up in three ICUs of the University Hospital Center Zagreb and one ICU in General Hospital Pula from September 2017 to March 2018. Antibiotic susceptibility was determined by broth microdilution method. Production of extended-spectrum β-lactamases (ESBLs) was determined by double-disk synergy test and carbapenemases by Hodge and carbapenem inactivation method (CIM). The genes encoding ESBLs, carbapenemases of class A, B and D and qnr genes were determined by PCR. In total 97 Gram- negative bacteria isolates were analyzed. P. aeruginosa demonstrated high resistance rates for imipenem and meropenem with 74% and 68% of resistant strains, respectively. Moderate resistance rates were observed for ceftazidime andpiperacillin/tazobactam, ciprofloxacin and gentamicin (44%). All except three A. baumannii isolates, were resistant to carbapenems and to all other antibiotics apart from colistin and amikacin. Eight A. baumannii isolates were positive for blaOXA-23 and 12 for blaOXA-24 genes. Four K. pneumoniae and two E. cloacae strains were ESBL positive and harboured group 1 of CTX-M β- lactamases. Three P. mirabilis strains were positive for plasmid-mediated ampC β-lactamase of CMY family. Two carbapenem-resistant K. pneumoniae harboured OXA-48 and one carbapenem-resistant E. cloacae VIM-1. A high proportion of multidrug- resistant P. aeruginosa, K. pneumoniae and extensively resistant A. baumannii was reported. Acquired resistance mechanisms, mainly production of carbapenemases and ESBLs were dominant in A. baumannii and K. pneumoniae, respectively. Resistance of P. aeruginosa isolates was more likely due to upregulation of efflux pumps or porin loss. A marked diversity of β-lactamases was identified in Enterobacteriaceae.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinički bolnički centar Zagreb,
Zdravstveno veleučilište, Zagreb

Poveznice na cjeloviti tekst rada:

doi www.tandfonline.com

Citiraj ovu publikaciju:

Bandić Pavlović, Daniela; Zah Bogović, Tajana; Žižek, Marta; Bijelan, Luka; Bratić, Vesna; Hrabač, Pero; Slačanac, Domagoj; Mihaljević, Slobodan; Bedenić, Branka
Gram-negative bacteria as causative agents of ventilator-associated pneumonia and their respective resistance mechanisms // Journal of chemotherapy, 32 (2020), 7; 344-358 doi:10.1080/1120009X.2020.1793594 (međunarodna recenzija, članak, znanstveni)
Bandić Pavlović, D., Zah Bogović, T., Žižek, M., Bijelan, L., Bratić, V., Hrabač, P., Slačanac, D., Mihaljević, S. & Bedenić, B. (2020) Gram-negative bacteria as causative agents of ventilator-associated pneumonia and their respective resistance mechanisms. Journal of chemotherapy, 32 (7), 344-358 doi:10.1080/1120009X.2020.1793594.
@article{article, author = {Bandi\'{c} Pavlovi\'{c}, Daniela and Zah Bogovi\'{c}, Tajana and \v{Z}i\v{z}ek, Marta and Bijelan, Luka and Brati\'{c}, Vesna and Hraba\v{c}, Pero and Sla\v{c}anac, Domagoj and Mihaljevi\'{c}, Slobodan and Bedeni\'{c}, Branka}, year = {2020}, pages = {344-358}, DOI = {10.1080/1120009X.2020.1793594}, keywords = {Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, Ventilator-associated pneumonia}, journal = {Journal of chemotherapy}, doi = {10.1080/1120009X.2020.1793594}, volume = {32}, number = {7}, issn = {1120-009X}, title = {Gram-negative bacteria as causative agents of ventilator-associated pneumonia and their respective resistance mechanisms}, keyword = {Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, Ventilator-associated pneumonia} }
@article{article, author = {Bandi\'{c} Pavlovi\'{c}, Daniela and Zah Bogovi\'{c}, Tajana and \v{Z}i\v{z}ek, Marta and Bijelan, Luka and Brati\'{c}, Vesna and Hraba\v{c}, Pero and Sla\v{c}anac, Domagoj and Mihaljevi\'{c}, Slobodan and Bedeni\'{c}, Branka}, year = {2020}, pages = {344-358}, DOI = {10.1080/1120009X.2020.1793594}, keywords = {Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, Ventilator-associated pneumonia}, journal = {Journal of chemotherapy}, doi = {10.1080/1120009X.2020.1793594}, volume = {32}, number = {7}, issn = {1120-009X}, title = {Gram-negative bacteria as causative agents of ventilator-associated pneumonia and their respective resistance mechanisms}, keyword = {Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, Ventilator-associated pneumonia} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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