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Pregled bibliografske jedinice broj: 1219939

MANIPULATION OF HNF1A, HNF4A AND FOXA2 USING CRISPR-BASED MOLECULAR TOOLS SUGGEST THEIR ROLE IN REGULATION OF PROTEIN GLYCOSYLATION IN LIVER AND PANCREATIC CELL MODELS


Vičić Bočkor, Vedrana; Klasić, Marija; Josipović, Goran; Vujić, Ana; Foglar, Nika; Smajlović, Samira; Keser, Toma; Lauc, Gordan; Vojta, Aleksandar; Zoldoš, Vlatka
MANIPULATION OF HNF1A, HNF4A AND FOXA2 USING CRISPR-BASED MOLECULAR TOOLS SUGGEST THEIR ROLE IN REGULATION OF PROTEIN GLYCOSYLATION IN LIVER AND PANCREATIC CELL MODELS // Journal of Bioanthropology
Zagreb: Institute for Anthropological Research, 2022. str. 153-153 doi:10.54062/jb (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1219939 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
MANIPULATION OF HNF1A, HNF4A AND FOXA2 USING CRISPR-BASED MOLECULAR TOOLS SUGGEST THEIR ROLE IN REGULATION OF PROTEIN GLYCOSYLATION IN LIVER AND PANCREATIC CELL MODELS
(MANIPULATION OF HNF1A, HNF4A AND FOXA2 USING CRISPR-BASED MOLECULAR TOOLS SUGGEST THEIR ROLE IN REGU)

Autori
Vičić Bočkor, Vedrana ; Klasić, Marija ; Josipović, Goran ; Vujić, Ana ; Foglar, Nika ; Smajlović, Samira ; Keser, Toma ; Lauc, Gordan ; Vojta, Aleksandar ; Zoldoš, Vlatka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Bioanthropology / - Zagreb : Institute for Anthropological Research, 2022, 153-153

Skup
ISABS CONFERENCE on Forensic and Anthropological Genetics and Mayo Clinic Lectures in Individualized Medicine

Mjesto i datum
Dubrovnik, Hrvatska, 22.-27. srpanj 2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
epigenetics, CRISPR/dCas9, glycogenes, protein glycosylation

Sažetak
Transcription factors HNF1A, HNF4A and FOXA1/2/3 regulate developmental and tissue-specific transcriptional gene networks in liver and pancreas.Alternative glycosylation affects protein structure and function, and aberrant protein glycosylation is observed in inflammation, diabetes and cancer.For instance, abnormal glucose stimulated insulin secretion in diabetes might occur through epigenetic changes in HNF1A and FOXA2, resulting in deregulation of MGAT4A, MGAT4B and MGAT5 glycosyltransferases responsible for proper glycosylaton of GLUT receptors on beta cells. In addition, HNF1A is identified by GWAS studies as a master regulator of key fucosyltransferases in liver.Following CRISPR-based manipulations, we analysed total protein glycosylation.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Vičić Bočkor, Vedrana; Klasić, Marija; Josipović, Goran; Vujić, Ana; Foglar, Nika; Smajlović, Samira; Keser, Toma; Lauc, Gordan; Vojta, Aleksandar; Zoldoš, Vlatka
MANIPULATION OF HNF1A, HNF4A AND FOXA2 USING CRISPR-BASED MOLECULAR TOOLS SUGGEST THEIR ROLE IN REGULATION OF PROTEIN GLYCOSYLATION IN LIVER AND PANCREATIC CELL MODELS // Journal of Bioanthropology
Zagreb: Institute for Anthropological Research, 2022. str. 153-153 doi:10.54062/jb (poster, međunarodna recenzija, sažetak, znanstveni)
Vičić Bočkor, V., Klasić, M., Josipović, G., Vujić, A., Foglar, N., Smajlović, S., Keser, T., Lauc, G., Vojta, A. & Zoldoš, V. (2022) MANIPULATION OF HNF1A, HNF4A AND FOXA2 USING CRISPR-BASED MOLECULAR TOOLS SUGGEST THEIR ROLE IN REGULATION OF PROTEIN GLYCOSYLATION IN LIVER AND PANCREATIC CELL MODELS. U: Journal of Bioanthropology doi:10.54062/jb.
@article{article, author = {Vi\v{c}i\'{c} Bo\v{c}kor, Vedrana and Klasi\'{c}, Marija and Josipovi\'{c}, Goran and Vuji\'{c}, Ana and Foglar, Nika and Smajlovi\'{c}, Samira and Keser, Toma and Lauc, Gordan and Vojta, Aleksandar and Zoldo\v{s}, Vlatka}, year = {2022}, pages = {153-153}, DOI = {10.54062/jb}, keywords = {epigenetics, CRISPR/dCas9, glycogenes, protein glycosylation}, doi = {10.54062/jb}, title = {MANIPULATION OF HNF1A, HNF4A AND FOXA2 USING CRISPR-BASED MOLECULAR TOOLS SUGGEST THEIR ROLE IN REGULATION OF PROTEIN GLYCOSYLATION IN LIVER AND PANCREATIC CELL MODELS}, keyword = {epigenetics, CRISPR/dCas9, glycogenes, protein glycosylation}, publisher = {Institute for Anthropological Research}, publisherplace = {Dubrovnik, Hrvatska} }
@article{article, author = {Vi\v{c}i\'{c} Bo\v{c}kor, Vedrana and Klasi\'{c}, Marija and Josipovi\'{c}, Goran and Vuji\'{c}, Ana and Foglar, Nika and Smajlovi\'{c}, Samira and Keser, Toma and Lauc, Gordan and Vojta, Aleksandar and Zoldo\v{s}, Vlatka}, year = {2022}, pages = {153-153}, DOI = {10.54062/jb}, keywords = {epigenetics, CRISPR/dCas9, glycogenes, protein glycosylation}, doi = {10.54062/jb}, title = {MANIPULATION OF HNF1A, HNF4A AND FOXA2 USING CRISPR-BASED MOLECULAR TOOLS SUGGEST THEIR ROLE IN REGU}, keyword = {epigenetics, CRISPR/dCas9, glycogenes, protein glycosylation}, publisher = {Institute for Anthropological Research}, publisherplace = {Dubrovnik, Hrvatska} }

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