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Trace and heavy metal impurity evaluation in dietary supplements used in the treatment of inflammatory bowel disease

Trace and heavy metal impurity in dietary supplements (DS) poses a serious potential risk to health. Furthermore, trace metals play a significant role in reactions that lead to the formation of the active chemical plant constituents and are responsible for their curative and toxic properties. For all mentioned above, this study aimed to evaluate the content of metal impurity in DS containing one or more plant species used to alleviate the symptoms of inflammatory bowel disease (IBD): Indian frankincense, Green chiretta and turmeric. Fifty- four collected samples were in different dosage forms: tablet, hard and soft capsule, tea mixture, bulk and tincture. Total Hg content in the studied samples was analyzed using mercury analyzer, while the contents of Ag, As, Ba, Cd, Co, Cr, Cu, Mo, Ni, Pb, Sb, Se and Sn were analyzed by GFAAS after microwave digestion. The obtained results of metal impurities were in a wide range. In conclusion, trace and heavy metal impurity in DS used in treating IBD were borderline or higher than the safety level. Notably, Pb and Hg posed the highest risk.

metal impurity, dietary supplements, inflammatory bowel diseases

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