engleski

The Significance Of Immunohistochemical Expression of CD44 And Ki67 In Patients With Oral Leukoplakia

Oral leukoplakia (OL) is a potentially malignant lesion of the oral mucosa with increased risk of malignant transformation compared to healthy mucosa. Today, many clinical, histopathological, and molecular factors are used as potential predictors of malignant transformation. The aim of the research is to immunohistochemically determine the presence of CD44 and Ki67 in OL and to compare the obtained data with the presence of CD44 and Ki67 in the oral squamous cell carcinoma (OSCC) and healthy oral mucosa (HOM). Thirty OL, 30 OSCC and 20 HOM were used for immunohistochemical analysis. Significant difference between groups in relation to the presence of CD44 and Ki67 in the epithelium were detected. Significant difference between groups in relation to the presence of CD44 in II were detected. Significant difference of Ki67 presence in II has been detected between OSCC and OL, OSCC and HOM, but not between OL and HOM. Positive correlations with CD44 both in the epithelium and in the II of OL were detected. Positive correlation between CD44 in inflammation with CD44 and Ki67 in the epithelium of OL were detected. Increased immunohistochemical presence of CD44 and Ki67 in OL may be a useful predictor of early changes in malignant transformation.

oral leukoplakia ; oral squamous cell cancer ; molecular markers ; Ki67 ; CD44

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