engleski

Microemulsions „Water in Oil“ as a Potential System for Ascorbic Acid Encapsulation

Microemulsions are optically isotropic and thermodynamically stable systems of water, oil and surfactant, often in combination with a cosurfactant which is required for optimal formation of microemulsion with a smaller aggregate radius and greater curvature of the interfacial layer. The full potential of microemulsion systems has yet to be realized and a lot of innovation in the field of microemulsion technology is expected. They have numerous advantages due to spontaneous formation, ease of manufacturing and scale-up, thermodynamic stability, ability to improve drug solubilization, and bioavailability. This work describes microemulsion systems which contain nonionic surfactants Tween 80 and Span 80, isopropyl myristate as the oil phase and purified water. From the most suitable microemulsion region, samples were selected and analyzed, blank and with encapsulated ascorbic acid, by measuring the size distribution of microemulsion aggregates, refractive index, electrical conductivity, and surface tension.

microemulsion ; micellization ; phase diagram ; surfactant ; cosurfactant ; dynamic light scattering ; refractive indeks ; electrical conductivity ; surface tension

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