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MECHANOCHEMICAL SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF NOVEL 1,2,3-TRIAZOLYL 2-ARYL BENZOTHIAZOLE DERIVATIVES

Benzothiazole derivatives exhibit various biological activities such as antitumor, antimicrobial, antiviral and anti-inflammatory. [1] Among the azoles, 1, 2, 3- triazoles are biological active compounds and attract a lot of attention as pharmachophore. Besides, triazole ring represents an ideal linker due its physical and chemical properties and can interact with biological targets such as DNA and proteins. One of the most famous drug containing a triazole linker is Ribavirin which is used for antiviral treatment. Furthermore, 2-mercaptobenzothiazole and 1, 2, 3-triazole derivative demonstrated potent selective COX-2 inhibition comparable with the standard drug ibuprofen. [2] Nowadays, more attention is focused on the synthesis of new biologically active agents by ecofriendly methodologies such as microwave-assisted and mechanochemical syntheses.

benzothiazole ; 1, 2, 3-triazole ; click chemistry ; mechanochemical reactions

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