engleski

Radiation sterilization of ketoprofen

Radiation sterilization of ketoprofen (KP) dry powder was investigated by selected physico-chemical methods. High performance liquid chromatography, ultraviolet spectrophotometry, infrared spectrophotometry, differential scanning calorimetry, X-ray diffraction and electron spin resonance spectroscopy did not show any significant degradation at 25 kGy. The irradiated KP did not show any difference of XRD patterns up to 200 kGy ; with DSC and IR some changes were detected only above 1000 and 2000 kGy, respectively ; HPLC has shown about 5% destruction at 2000 kGy. Acetyl benzophenon (AcBph) was generated by irradiation with G(AcBph) = (1.6+-0.1) . 10-8 mol J-1. Ames test has shown no mutagenicity of KP irradiated with 3000 kGy or of the oily mixture of radiolytic products isolated from it. Solid KP has proven to be very stable on irradiation, and irradiation has been found a suitable method for its sterilization.

ketoprofen; radiation sterilization; degradation; DSC; ESR; HPLC; IR; UV; XRD; Ames test

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