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Pregled bibliografske jedinice broj: 1217646

EFFECTS OF A SINGLE MODERATE TRAUMATIC BRAIN INJURY IN MOUSE ON THE TAR DNA-BINDING PROTEIN 43 AND ITS CONNECTION WITH NEUROINFLAMMATION AND SYNAPTIC PLASTICITY


Janković, Tamara; Gržeta, Nika; Rajič Bumber, Jelena; Dolenec, Petra; Križ, Jasna; Župan, Gordana; Pilipović, Kristina
EFFECTS OF A SINGLE MODERATE TRAUMATIC BRAIN INJURY IN MOUSE ON THE TAR DNA-BINDING PROTEIN 43 AND ITS CONNECTION WITH NEUROINFLAMMATION AND SYNAPTIC PLASTICITY // Pharmaca
Opatija, Hrvatska, 2022. str. 119-119 (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1217646 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
EFFECTS OF A SINGLE MODERATE TRAUMATIC BRAIN INJURY IN MOUSE ON THE TAR DNA-BINDING PROTEIN 43 AND ITS CONNECTION WITH NEUROINFLAMMATION AND SYNAPTIC PLASTICITY
(EFFECTS OF A SINGLE MODERATE TRAUMATIC BRAIN INJURY IN MOUSE ON THE TAR DNA-BINDING PROTEIN 43 AND ITS CONNECTION WITH NEUROINFLAMMATION AND SYNAPTIC PLASTICITY)

Autori
Janković, Tamara ; Gržeta, Nika ; Rajič Bumber, Jelena ; Dolenec, Petra ; Križ, Jasna ; Župan, Gordana ; Pilipović, Kristina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Pharmaca / - , 2022, 119-119

Skup
10th Croatian Congress of Pharmacology and the 1st Croatian Congress of Clinical Pharmacology with International Participation

Mjesto i datum
Opatija, Hrvatska, 22.09.2022. - 25.09.2022

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
TDP-43, Cortex, Hippocampus, Traumatic brain injury

Sažetak
Traumatic brain injury (TBI) is a lifelong condition that leads to progressive brain damage and cognitive disturbances. TBI has been recognized as a risk factor for the development of numerous neurodegenerative diseases, such as Alzheimer and Parkinson’s disease, amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Proteinopathy of TAR DNA binding protein 43 (TDP-43) is considered the most important pathological characteristic of ALS and FTLD, that is characterized by permanent translocation of TDP-43 in the cytoplasm where this protein undergoes hyperphosphorylation, ubiquitination and fragmentation with subsequent inclusion formation. Toxic effects of TDP-43 inclusions have been demonstrated in the neurons and microglia, but deficiency of nuclear TDP-43 has numerous cell consequences too. Although cellular processes that induce TDP-43 proteinopathy are still unclear, it has been proven that inflammation can induce these changes. Interconnection of TDP-43 with some synaptic proteins has also been found. TDP-43 inclusions have been detected in the brain tissue after repetitive trauma in numerous clinical and preclinical investigations and it is mostly considered that this type of proteinopathy is only a consequence of repetitive, but with a single TBI, results have thus far been inconclusive. The aim of this study was to investigate the changes in the TDP- 43 localization, fragmentation, and phosphorylation in different brain regions after a single moderate TBI in mice. Additionally, we examined the association of TDP-43 expression with some markers of synaptogenesis and inflammation. This work was supported by the University of Rijeka, Croatia, project-uniri- biomed-18-199 to K.P. and Croatian Science Foundation project-IP-2016-06-4602 to GŽ.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
NadSve-uniri-biomed-18-199 - Molekularni mehanizmi neurodegeneracije u traumatskoj ozljedi mozga: uloga TAR DNA-vezujućeg proteina 43 (Pilipović, Kristina, NadSve ) ( CroRIS)
HRZZ-IP-2016-06-4602 - Blaga repetitivna traumatska ozljeda mozga: model za istraživanje neuropatologije i neuroupale posredovane s TDP-43 (TDP-43repTBI) (Župan, Gordana, HRZZ - 2016-06) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju:

Janković, Tamara; Gržeta, Nika; Rajič Bumber, Jelena; Dolenec, Petra; Križ, Jasna; Župan, Gordana; Pilipović, Kristina
EFFECTS OF A SINGLE MODERATE TRAUMATIC BRAIN INJURY IN MOUSE ON THE TAR DNA-BINDING PROTEIN 43 AND ITS CONNECTION WITH NEUROINFLAMMATION AND SYNAPTIC PLASTICITY // Pharmaca
Opatija, Hrvatska, 2022. str. 119-119 (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)
Janković, T., Gržeta, N., Rajič Bumber, J., Dolenec, P., Križ, J., Župan, G. & Pilipović, K. (2022) EFFECTS OF A SINGLE MODERATE TRAUMATIC BRAIN INJURY IN MOUSE ON THE TAR DNA-BINDING PROTEIN 43 AND ITS CONNECTION WITH NEUROINFLAMMATION AND SYNAPTIC PLASTICITY. U: Pharmaca.
@article{article, author = {Jankovi\'{c}, Tamara and Gr\v{z}eta, Nika and Raji\v{c} Bumber, Jelena and Dolenec, Petra and Kri\v{z}, Jasna and \v{Z}upan, Gordana and Pilipovi\'{c}, Kristina}, year = {2022}, pages = {119-119}, keywords = {TDP-43, Cortex, Hippocampus, Traumatic brain injury}, title = {EFFECTS OF A SINGLE MODERATE TRAUMATIC BRAIN INJURY IN MOUSE ON THE TAR DNA-BINDING PROTEIN 43 AND ITS CONNECTION WITH NEUROINFLAMMATION AND SYNAPTIC PLASTICITY}, keyword = {TDP-43, Cortex, Hippocampus, Traumatic brain injury}, publisherplace = {Opatija, Hrvatska} }
@article{article, author = {Jankovi\'{c}, Tamara and Gr\v{z}eta, Nika and Raji\v{c} Bumber, Jelena and Dolenec, Petra and Kri\v{z}, Jasna and \v{Z}upan, Gordana and Pilipovi\'{c}, Kristina}, year = {2022}, pages = {119-119}, keywords = {TDP-43, Cortex, Hippocampus, Traumatic brain injury}, title = {EFFECTS OF A SINGLE MODERATE TRAUMATIC BRAIN INJURY IN MOUSE ON THE TAR DNA-BINDING PROTEIN 43 AND ITS CONNECTION WITH NEUROINFLAMMATION AND SYNAPTIC PLASTICITY}, keyword = {TDP-43, Cortex, Hippocampus, Traumatic brain injury}, publisherplace = {Opatija, Hrvatska} }




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