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Pregled bibliografske jedinice broj: 1217638

THE EFFECTS OF REPETITIVE MILD TRAUMATIC BRAIN INJURY ON SOME PROTEINOPATHY SUSCEPTIBLE PROTEINS IN THE MOUSE FRONTAL CORTEX


Janković, Tamara; Gržeta, Nika; Rajič Bumber, Jelena; Dolenec, Petra; Križ, Jasna; Župan, Gordana; Pilipović, Kristina
THE EFFECTS OF REPETITIVE MILD TRAUMATIC BRAIN INJURY ON SOME PROTEINOPATHY SUSCEPTIBLE PROTEINS IN THE MOUSE FRONTAL CORTEX // Pharmaca
Opatija, Hrvatska, 2022. str. 165-165 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1217638 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
THE EFFECTS OF REPETITIVE MILD TRAUMATIC BRAIN INJURY ON SOME PROTEINOPATHY SUSCEPTIBLE PROTEINS IN THE MOUSE FRONTAL CORTEX

Autori
Janković, Tamara ; Gržeta, Nika ; Rajič Bumber, Jelena ; Dolenec, Petra ; Križ, Jasna ; Župan, Gordana ; Pilipović, Kristina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Pharmaca / - , 2022, 165-165

Skup
10th Croatian Congress of Pharmacology and the 1st Croatian Congress of Clinical Pharmacology with International Participation

Mjesto i datum
Opatija, Hrvatska, 22.09.2022. - 25.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Amyloid-beta precursor protein, TAU protein, TDP-43, Cortex, Traumatic brain injury

Sažetak
Introduction: Traumatic brain injury (TBI) is an important healthcare problem leading to lifelong repercussions that burden society. Primary brain injury is irreversible, but secondary TBI includes many pathophysiological processes, including the development of proteinopathies that contribute to cognitive impairment. This study aimed to investigate the expression of amyloid-beta precursor protein (APP), phosphorylated Tau protein (pTau) and TAR-DNA binding protein 43 (TDP-43) in the frontal cortex of C57BL/6 mice 14 days after mild repetitive traumas. Selected proteins are susceptible to pathological misfolding and are proven to contribute to the clinicopathological spectrum of dementias developing after TBI. Materials/Methods: Repetitive mild brain traumas were applied by the weight drop method, twice per day, 5 days in a row. Injured animals were sacrificed 14 days after the last brain trauma and their frontal cortices were prepared for western blot or immunohistological analyses. Control group of animals were sacrificed one day after the sham injury procedure. Results: At 14 days post-injury, a significant increase in the cortical expression levels of total and mature APP was detected, while pTau positive cells were not found. A significant increase in the TDP-43 levels was detected only in the nucleus, but cytoplasmic mislocalization and phosphorylation were not found after mild repetitive TBI. Conclusions: Our preliminary results showed that repetitive brain traumas lead to changes in APP levels at 14 days, without the formation of pathological pTau and TDP-43 species. This work was supported by the University of Rijeka, Croatia, project-uniri-biomed-18-199 to K.P. and Croatian Science Foundation project-IP-2016-06-4602 to GŽ.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-4602 - Blaga repetitivna traumatska ozljeda mozga: model za istraživanje neuropatologije i neuroupale posredovane s TDP-43 (TDP-43repTBI) (Župan, Gordana, HRZZ - 2016-06) ( CroRIS)
NadSve-uniri-biomed-18-199 - Molekularni mehanizmi neurodegeneracije u traumatskoj ozljedi mozga: uloga TAR DNA-vezujućeg proteina 43 (Pilipović, Kristina, NadSve ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju:

Janković, Tamara; Gržeta, Nika; Rajič Bumber, Jelena; Dolenec, Petra; Križ, Jasna; Župan, Gordana; Pilipović, Kristina
THE EFFECTS OF REPETITIVE MILD TRAUMATIC BRAIN INJURY ON SOME PROTEINOPATHY SUSCEPTIBLE PROTEINS IN THE MOUSE FRONTAL CORTEX // Pharmaca
Opatija, Hrvatska, 2022. str. 165-165 (poster, međunarodna recenzija, sažetak, znanstveni)
Janković, T., Gržeta, N., Rajič Bumber, J., Dolenec, P., Križ, J., Župan, G. & Pilipović, K. (2022) THE EFFECTS OF REPETITIVE MILD TRAUMATIC BRAIN INJURY ON SOME PROTEINOPATHY SUSCEPTIBLE PROTEINS IN THE MOUSE FRONTAL CORTEX. U: Pharmaca.
@article{article, author = {Jankovi\'{c}, Tamara and Gr\v{z}eta, Nika and Raji\v{c} Bumber, Jelena and Dolenec, Petra and Kri\v{z}, Jasna and \v{Z}upan, Gordana and Pilipovi\'{c}, Kristina}, year = {2022}, pages = {165-165}, keywords = {Amyloid-beta precursor protein, TAU protein, TDP-43, Cortex, Traumatic brain injury}, title = {THE EFFECTS OF REPETITIVE MILD TRAUMATIC BRAIN INJURY ON SOME PROTEINOPATHY SUSCEPTIBLE PROTEINS IN THE MOUSE FRONTAL CORTEX}, keyword = {Amyloid-beta precursor protein, TAU protein, TDP-43, Cortex, Traumatic brain injury}, publisherplace = {Opatija, Hrvatska} }
@article{article, author = {Jankovi\'{c}, Tamara and Gr\v{z}eta, Nika and Raji\v{c} Bumber, Jelena and Dolenec, Petra and Kri\v{z}, Jasna and \v{Z}upan, Gordana and Pilipovi\'{c}, Kristina}, year = {2022}, pages = {165-165}, keywords = {Amyloid-beta precursor protein, TAU protein, TDP-43, Cortex, Traumatic brain injury}, title = {THE EFFECTS OF REPETITIVE MILD TRAUMATIC BRAIN INJURY ON SOME PROTEINOPATHY SUSCEPTIBLE PROTEINS IN THE MOUSE FRONTAL CORTEX}, keyword = {Amyloid-beta precursor protein, TAU protein, TDP-43, Cortex, Traumatic brain injury}, publisherplace = {Opatija, Hrvatska} }




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