engleski

Polyphenols from Prunus spinosa L. flower extract can impact on insulin level in hyperglycemic C57BL/6 mice

The use of plant extracts in treatment of hyperglycemia is well known in tradicional medicine. In this research we questioned if polyphenols from Prunus spinosa L. (PSE) extract can have impact on serum insulin levels after 10 days intake of 25 mg kg-1 bm of total polyphenols in hyperglycemic C57BL/6 mice. Hyperglycemia was induced with 150 mg kg-1 bm of alloxan. Total of 4 groups of mice: (1) as control (C), (2) as Prunus spinosa L. flower extract (PSE), (3) as alloxan group (AL) and (4) as Alloxan group treated with PSE (AL+PSE) were subjected to research. The PSE intake resulted in higher serum insulin levels, but not significantly, in Prunus spinosa L. flower extract group compared to control group on day 1 of experiment. When the Prunus spinosa L. flower extract was administrated to the hyperglycemic mice (AL+PSE) there was a significant increase of insulin levels on day 10 of experiment (P=0, 0183) compared to alloxan (AL) group. This means that 10 consecutive daily doses of PSE consumption had positive impact on insulin secretion. These findings may be used in designing a nutraceutical polyphenol mixture as a supportive therapy in hyperglycemia managment. In conclusion this research shows that 10 days intake of Prunus spinosa L. flower extract can have protective effect on pancreatic beta cells and therefore enhance serum insulin level.

hyperglycemia, insulin, mice, polyphenols, Prunus spinosa L.

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