engleski

Latent Structure of Dermatoglyphs in Gastric Cancer

Gastric cancer is a very common malignant disease, which etiology is still unknown. It is believed that it is caused by a joint activity of both genetic and environmental factors. Gastric cancer between relatives in some families is almost four times higher and in connection with truncating mutations in the E-cadherin gene. The Helicobacter pylori increases the cancer risk by about 5 times. Digito-palmar dermatoglyphics have already been used for determining hereditary base of some malignant diseases (breast, lung, colorectal cancer etc.), which gives an important impetus towards investigations of the latent structure in patients with gastric cancer (36 males and 32 females) and the control groups (200 males and 200 females). The factor analysis has shown that in both males and females with gastric cancer 5 factors were extracted and in males 79.65% and in females 79.58% of total variance was explained, and this result is different from control group where in males 5 factors and 72.37% of total variance were explained while in control females 6 factors and 76.57% of total variance were explained. The palmar ridge counts are extracted on the first factor in all groups, but extraction of the b-c ridge count and c-d ridge count together is found in male patients on the second factor and in the female patients on the third factor. In control groups those variables are extracted separately. From the obtained findings it can be concluded that the results of latent structure in quantitative analysis of digito-palmar dermatoglyphics are affirming the existence of genetic differences in patients suffered with gastric cancer.

dermatoglyphs; gastric cancer; latent structure; Croatia

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