engleski

Oxidative stress level in children with essential arterial hypertension

Objective: Oxidative stress may play an important role in the pathophysiology of hypertension. Isoprostanes, a group of prostaglandin-like compounds, active products of arachidonic acid, have proved to be representative biomarkers of lipid peroxidation. This study aimed to determine the influence of essential arterial hypertension on serum concentration of 8-iso-prostaglandin F2alpha, (8-iso-PGF2α), as an in vivo oxidative stress marker in children. Design and Method: Total of 52 children participated in this study: 26 children with essential arterial hypertension (HT) and 26 normotensive children (NT) (both sexes, age ranged 8-17). In addition to arterial blood pressure and heart rate, body mass index (BMI) was measured for all subjects. In the venous blood sample, the concentration of serum 8-iso- PGF2α was determined using the ELISA method. Statistical analysis was conducted by nonparametric Mann-Whitney U test (between groups), and Pearson’s correlation test was used to determine the correlations between 8- iso-PGF2α and blood pressure. p< 0.05 was considered statistically significant. Results: Body mass index (BMI) was significantly higher in hypertensive children compared to normotensive children, but waist to hip ratio (WHR) was similar between groups. Children with essential arterial hypertension had significantly higher systolic (SBP), diastolic (DBP) and mean (MAP) arterial blood pressure compared to normotensive children, while there was no difference in heart rate. Serum concentration of 8-iso-PGF2α was significantly higher in HT group compared to the NT group (adjusted for BMI). Futhermore, 8-iso- PGF2α was positively associated with SBP (r=0, 468) and MAP (r=0, 366). Conclusions: Results support the hypothesis that already in childhood, arterial hypertension is accompanied by an elevated level of oxidative stress, independently of BMI. Acknowledgement: This study was supported by institutional grants from the Faculty of Medicine Osijek IP9-2021-MEFOS grant (PI Ivana Jukić) and IP17-2022-MEFOS grant (PI Ivana Jukić).

Oxidative stress ; Children ; Essential Arterial Hypertension

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