Characterisation and toxicological activity of three different Pseudo-nitzschia species from the northern Adriatic Sea (Croatia) (CROSBI ID 314373)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Smodlaka Tanković, Mirta ; Baričević, Ana ; Gerić, Marko ; Domijan, Ana-Marija ; Marić Pfannkuchen, Daniela ; Kužat, Nataša ; Ujević, Ivana ; Kuralić, Malissa ; Rožman, Marko ; Matković, Katarina ; Novak, Matjaž ; Žegura, Bojana ; Pfannkuchen, Martin ; Gajski, Goran
engleski
Characterisation and toxicological activity of three different Pseudo-nitzschia species from the northern Adriatic Sea (Croatia)
Diatoms of the genus Pseudo-nitzschia are cosmopolitans spread in seas and oceans worldwide, with more than 50 described species, dozens of which have been confirmed to produce domoic acid (DA). Here, we characterized and investigated the toxicological activity of secondary metabolites excreted into the growth media of different Pseudo-nitzschia species sampled at various locations in the northern Adriatic Sea (Croatia) using human blood cells under in vitro conditions. The results revealed that three investigated species of the genus Pseudo-nitzschia were capable of producing DA indicating their toxic potential. Moreover, toxicological data suggested all three Pseudo-nitzschia species can excrete toxic secondary metabolites into the surrounding media in addition to the intracellular pools of DA, raising concerns regarding their toxicity and environmental impact. In addition, all three Pseudo-nitzchia species triggered oxidative stress, one of the mechanisms of action likely responsible for the DNA damage observed in human blood cells. In line with the above stated, our results are of great interest to environmental toxicologists, the public and policy makers, especially in light of today's climate change, which favours harmful algal blooms and the growth of DA producers with a presumed negative impact on the public health of coastal residents.
Pseudo-nitzschia ; Domoic acid ; human peripheral blood cells ; Cyto/genotoxicity ; environmental safety
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Podaci o izdanju
214
2022.
114108
12
objavljeno
0013-9351
1096-0953
10.1016/j.envres.2022.114108
Povezanost rada
Biologija, Interdisciplinarne prirodne znanosti, Kemija