Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

Citotoksično djelovanje tieno[2,3-b]piridinskih spojeva na stanice humanog karcinoma mokraćnog mjehura (CROSBI ID 451942)

Ocjenski rad | diplomski rad

Kalezić, Denis Citotoksično djelovanje tieno[2,3-b]piridinskih spojeva na stanice humanog karcinoma mokraćnog mjehura / Čikeš Čulić, Vedrana (mentor); Split, Medicinski fakultet u Splitu, . 2022

Podaci o odgovornosti

Kalezić, Denis

Čikeš Čulić, Vedrana

engleski

Citotoksično djelovanje tieno[2,3-b]piridinskih spojeva na stanice humanog karcinoma mokraćnog mjehura

Objectives: The purpose of this study was to determine the effects of treating bladder cancer cells with the newly synthesized thieno[2, 3- b]pyridine anticancer agents, by focusing on its cytotoxic effects on the investigated human cell line T24. Methods: The T24 bladder cancer cell line was treated with a newly developed thieno[2, 3- b]pyridine anticancer compounds: Inhibitor 5 3- amino-N-(3-chloro-2-methylphenyl)-5-oxo-5, 6, 7, 8- tetrahydrothieno[2, 3-b]quinoline-2-carboxamide, Inhibitor 6 3-amino-N-(naphthalen-1-yl)-5-oxo- 5, 6, 7, 8-tetrahydrothieno[2, 3-b]quinoline-2- carboxamide, Inhibitor 8 (E)-3-amino-5-(3-(3- bromophenyl)acryloyl)-N-(3-chloro-2- methylphenyl)-6-methylthieno[2, 3-b]pyridine-2- carboxamide and Inhibitor 9 (E)-3-amino-5-(3-(3- bromophenyl)-1-hydroxyallyl)-N-(3-chloro-2- methylphenyl)-6-methylthieno[2, 3-b]pyridine-2- carboxamide to determine its cytotoxic effect on T24 cells. The 3-(4, 5-dimethylthiazolyl-2)-2, 5- diphenyltetrazolium bromide (MTT) assay was performed to analyze the cellular metabolic activity and determine the cytotoxic effect. Results: Inhibitors 5, 6, 8 and 9 all showed significant cytotoxic effect on the bladder cancer cells in a dose- and time-dependent manner. The most effective was Inhibitor 8 with an IC50 value of 0.4041 µg/mL after 72 hours. Conclusion: Due to their cytotoxic effect on bladder cancer cells, Inhibitors 5, 6, 8 and 9 deserve further attention as a potential treatment for transitional cell cancer.

karcinom mokraćnog mjehura, tieno-piridinski derivati

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

49

15.09.2022.

obranjeno

Podaci o ustanovi koja je dodijelila akademski stupanj

Medicinski fakultet u Splitu

Split

Povezanost rada

Temeljne medicinske znanosti