engleski

Serum levels of 25-hydroxyvitamin D3 among students of Faculty of Medicine Osijek and its correlation with body mass index

Introduction: Vitamin D is a fat-soluble vitamin with steroid structure. A great number of epidemiological studies suggest an increasing presence of hypovitaminosis of vitamin D among humans. Vitamin D deficiency itself is defined by serum levels of 25-hydroxyvitamin D3 (25-OH-D3) below 20 ng/mL. The aim of this study was to evaluate serum levels of 25-hydroxyvitamin D3 among students of the Faculty of Medicine Osijek and to assess correlation with body mass index (BMI). Materials and methods: Concentration of 25-OH-D3 were measured by LC/MS-MS procedure on Shimadzu LCMS 8050, using RECIPE kit for serum levels of 25-OH-D3 and 25-OH-D2. BMI and percentage of body fat were measured using bioelectrical impedance analysis. In order to determine the normality of the distribution of numerical data, the D'Agostino - Pearson test was performed. The Pearson and Spearman correlation coefficients were calculated. The significance level is set to alfa = 0.05. 60 respondents participated in the research. Of these, 16 are men (26, 7%) and 44 are women (73, 3%). Results: Mean value for serum levels of 25-OH-D3 ws 11.37 ng/mL (SD = 1.60). D'Agostino-Pearson test showed a significant deviation from the normal distribution for BMI (p = 2.38 * 10 on 7, p < a) and body fat percentage (p = 0.0259, p < a). By conducting a Spearman test, there was found no correlation between he percentage of body fat and the concentration of 25-OH-D3 (r, = 0.151, P = 0.249) and no correlation between BMI and 25-OH-D3 levels (r ; = 0.169, p = 0.196) Conclusion: Serum levels of 25-OH-D3 are below expected, therefore presenting a potential risk factor for development of various health conditions. No correlation of vitamin D to BMI was found.

25-hydroxyvitamin D3 ; body mass index ; vitamin d

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