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Terpenes and Cannabinoids in Supercritical CO2 Extracts of Industrial Hemp Inflorescences: Optimization of Extraction, Antiradical and Antibacterial Activity (CROSBI ID 313642)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Jokić, Stela ; Jerković, Igor ; Pavić, Valentina ; Aladić, Krunoslav ; Molnar, Maja ; Jakovljević Kovač, Martina ; Vladimir-Knežević, Sanda Terpenes and Cannabinoids in Supercritical CO2 Extracts of Industrial Hemp Inflorescences: Optimization of Extraction, Antiradical and Antibacterial Activity // Pharmaceuticals, 15 (2022), 9; 1117, 21. doi: 10.3390/ph15091117

Podaci o odgovornosti

Jokić, Stela ; Jerković, Igor ; Pavić, Valentina ; Aladić, Krunoslav ; Molnar, Maja ; Jakovljević Kovač, Martina ; Vladimir-Knežević, Sanda

engleski

Terpenes and Cannabinoids in Supercritical CO2 Extracts of Industrial Hemp Inflorescences: Optimization of Extraction, Antiradical and Antibacterial Activity

Natural products are increasingly in demand in dermatology and cosmetology. In the present study, highly valuable supercritical CO2 (sCO2) extracts rich in bioactive compounds with antiradical and antibacterial activity were obtained from the inflorescences of industrial hemp. Volatile compounds were analyzed by gas chromatography in tandem with mass spectrometry (GCMS), while cannabinoids were determined by high performance liquid chromatography (HPLC DAD). Extraction yields varied from 0.75 to 8.83%, depending on the pressure and temperature applied. The extract obtained at 320 bar and 40 °C with the highest content (305.8 µg mg−1) of cannabidiolic acid (CBDA) showed the best antiradical properties. All tested extract concentrations from 10.42 µg mL−1 to 66.03 µg mL−1 possessed inhibitory activities against E. coli, P. aeruginosa, B. subtilis, and S. aureus. The sCO2 extract with the highest content of cannabidiol (CBD) and rich in αpinene, β-pinene, β-myrcene, and limonene was the most effective. The optimal conditions for sCO2 extraction of cannabinoids and volatile terpenes from industrial hemp were determined. The temperature of 60 °C proved to be optimal for all responses studied, while the pressure showed a different effect depending on the compounds targeted. A low pressure of 131.2 bar was optimal for the extraction of monoterpenes, while extracts rich in sesquiterpenes were obtained at 319.7 bar. A high pressure of 284.78 bar was optimal for the extraction of CBD.

Cannabis sativa ; industrial hemp ; supercritical CO2 extraction ; terpenes ; cannabinoids ; antiradical activity ; antibacterial activity

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Podaci o izdanju

15 (9)

2022.

1117

21

objavljeno

1424-8247

10.3390/ph15091117

Povezanost rada

Farmacija

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