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Renal disease associated with chronic myeloproliferative neoplasms (CROSBI ID 313515)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Lucijanić, Marko ; Krečak, Ivan ; Kušec, Rajko Renal disease associated with chronic myeloproliferative neoplasms // Expert review of hematology, 15 (2022), 2; 93-96. doi: 10.1080/17474086.2022.2039117

Podaci o odgovornosti

Lucijanić, Marko ; Krečak, Ivan ; Kušec, Rajko

engleski

Renal disease associated with chronic myeloproliferative neoplasms

Patients with BCR-ABL negative chronic myeloproliferative neoplasms (MPNs) present with chronic kidney disease (CKD) in up to one third of cases. These patients are known to have increased cardiovascular risk and usually present with features of stronger myeloproliferation. In recent years CKD has gained attention in MPN patients as a potential renal manifestation of the disease termed MPN-related glomerulopathy. This view has been supported mainly by evidence from kidney biopsies and renal post- mortem autopsy findings of MPN patients, as well as by clinical observations of improvement/slower deterioration of renal function after institution of specific therapies in some MPN cohorts. All current evidence is based only on retrospective datasets which are known to be susceptible to different types of bias. Prospectively designed interventional studies are needed to properly understand true effects of CKD and its control by differently targeted (CKD and MPN directed) therapies.

Glomerular sclerosis ; MPN related glomerulopathy ; chronic kidney disease ; polycythemia vera ; primary myelofibrosis ; essential thrombocythemia

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Podaci o izdanju

15 (2)

2022.

93-96

objavljeno

1747-4086

1747-4094

10.1080/17474086.2022.2039117

Povezanost rada

Kliničke medicinske znanosti

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