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Pregled bibliografske jedinice broj: 1211184

Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery


Perkušić, Mirna; Nižić Nodilo, Laura; Ugrina, Ivo; Špoljarić, Drago; Jakobušić Brala, Cvijeta; Pepić, Ivan; Lovrić, Jasmina; Matijašić, Gordana; Gretić, Matija; Zadravec, Dijana et al.
Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery // International journal of pharmaceutics, 624 (2022), 122038, 15 doi:10.1016/j.ijpharm.2022.122038 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1211184 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery

Autori
Perkušić, Mirna ; Nižić Nodilo, Laura ; Ugrina, Ivo ; Špoljarić, Drago ; Jakobušić Brala, Cvijeta ; Pepić, Ivan ; Lovrić, Jasmina ; Matijašić, Gordana ; Gretić, Matija ; Zadravec, Dijana ; Kalogjera, Livije ; Hafner, Anita

Izvornik
International journal of pharmaceutics (0378-5173) 624 (2022); 122038, 15

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
spray-drying ; ultrasonic nozzle ; nose-to-brain powder delivery ; donepezil ; olfactory deposition

Sažetak
Shortcomings of oral donepezil administration in the treatment of Alzheimer’s disease have paved the way for ongoing investigations towards more efficient and safe donepezil nose-to-brain delivery. Herein we present the development of advantageous powder platform for donepezil nose- to-brain delivery, coupling careful design of chitosan and mannitol-based carrier matrix with spray-drying technology advantages and early consideration of adequate nasal administration mode, employing QbD approach. Unprecedentedly, ultrasonic nozzle was used to atomise the drying feed in response to size-related requirements for nasal aerosol particles. The optimised spray- drying process resulted in free-flowable dry powder with a great majority of particles larger than 10 µm, ensuring localised nasal deposition upon aerosolization, as evidenced by using 3D- printed nasal cavity model. QbD approach coupling formulation, process and administration parameters enabled optimisation of drug deposition profile reaching tremendously high 65.5 % of the applied dose deposited in the olfactory region. The leading formulation exhibited favourable swelling, mucoadhesion, drug release and permeation- enhancing properties, suiting the needs for efficient brain-targeted delivery. Results of in vitro biocompatibility and physico-chemical stability studies confirmed the leading formulation potential for safe and efficient donepezil nose-to-brain delivery. The obtained results encourage extending the study to an appropriate in vivo model needed for the final proof-of-concept.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekti:
HRZZ-UIP-2017-05-4592 - Optimiranje depozicije raspršenih in situ gelirajućih i praškastih terapijskih sustava u nosnoj šupljini (OptiNasalSpray) (Hafner, Anita, HRZZ - 2017-05) ( CroRIS)
EK-EFRR-KK.01.1.1.02.0021 - Jačanje znanstveno-istraživačkih i inovacijskih kapaciteta Farmaceutsko-biokemijskog fakulteta Sveučilišta u Zagrebu (FarmInova) (Lovrić, Jasmina, EK - Ulaganje u organizacijsku reformu i infrastrukturu u sektoru istraživanja, razvoja i inovacija) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
KBC "Sestre Milosrdnice",
Prirodoslovno-matematički fakultet, Split,
Genera d.d.

Poveznice na cjeloviti tekst rada:

doi dx.doi.org www.sciencedirect.com

Citiraj ovu publikaciju:

Perkušić, Mirna; Nižić Nodilo, Laura; Ugrina, Ivo; Špoljarić, Drago; Jakobušić Brala, Cvijeta; Pepić, Ivan; Lovrić, Jasmina; Matijašić, Gordana; Gretić, Matija; Zadravec, Dijana et al.
Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery // International journal of pharmaceutics, 624 (2022), 122038, 15 doi:10.1016/j.ijpharm.2022.122038 (međunarodna recenzija, članak, znanstveni)
Perkušić, M., Nižić Nodilo, L., Ugrina, I., Špoljarić, D., Jakobušić Brala, C., Pepić, I., Lovrić, J., Matijašić, G., Gretić, M. & Zadravec, D. (2022) Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery. International journal of pharmaceutics, 624, 122038, 15 doi:10.1016/j.ijpharm.2022.122038.
@article{article, author = {Perku\v{s}i\'{c}, Mirna and Ni\v{z}i\'{c} Nodilo, Laura and Ugrina, Ivo and \v{S}poljari\'{c}, Drago and Jakobu\v{s}i\'{c} Brala, Cvijeta and Pepi\'{c}, Ivan and Lovri\'{c}, Jasmina and Matija\v{s}i\'{c}, Gordana and Greti\'{c}, Matija and Zadravec, Dijana and Kalogjera, Livije and Hafner, Anita}, year = {2022}, pages = {15}, DOI = {10.1016/j.ijpharm.2022.122038}, chapter = {122038}, keywords = {spray-drying, ultrasonic nozzle, nose-to-brain powder delivery, donepezil, olfactory deposition}, journal = {International journal of pharmaceutics}, doi = {10.1016/j.ijpharm.2022.122038}, volume = {624}, issn = {0378-5173}, title = {Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery}, keyword = {spray-drying, ultrasonic nozzle, nose-to-brain powder delivery, donepezil, olfactory deposition}, chapternumber = {122038} }
@article{article, author = {Perku\v{s}i\'{c}, Mirna and Ni\v{z}i\'{c} Nodilo, Laura and Ugrina, Ivo and \v{S}poljari\'{c}, Drago and Jakobu\v{s}i\'{c} Brala, Cvijeta and Pepi\'{c}, Ivan and Lovri\'{c}, Jasmina and Matija\v{s}i\'{c}, Gordana and Greti\'{c}, Matija and Zadravec, Dijana and Kalogjera, Livije and Hafner, Anita}, year = {2022}, pages = {15}, DOI = {10.1016/j.ijpharm.2022.122038}, chapter = {122038}, keywords = {spray-drying, ultrasonic nozzle, nose-to-brain powder delivery, donepezil, olfactory deposition}, journal = {International journal of pharmaceutics}, doi = {10.1016/j.ijpharm.2022.122038}, volume = {624}, issn = {0378-5173}, title = {Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery}, keyword = {spray-drying, ultrasonic nozzle, nose-to-brain powder delivery, donepezil, olfactory deposition}, chapternumber = {122038} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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  • CA Search (Chemical Abstracts)


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