Utilization of olive pomace in green synthesis of selenium nanoparticles: physico-chemical characterization, bioaccessibility and biocompatibility (CROSBI ID 313214)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Galić, Emerik ; Radić, Kristina ; Golub, Nikolina ; Vitali Čepo, Dubravka ; Kalčec, Nikolina ; Vrček, Ena ; Vinković, Tomislav
engleski
Utilization of olive pomace in green synthesis of selenium nanoparticles: physico-chemical characterization, bioaccessibility and biocompatibility
Olive pomace extract (OPE) was investigated as a potential surface modifier for the development of the green synthesis process of selenium nanoparticles (SeNPs). In order to evaluate them as potential nutraceuticals, the obtained nanosystems were characterized in terms of size distribution, shape, zeta potential, stability in different media, gastrointestinal bioaccessibility and biocompatibility. Systems with a unimodal size distribution of spherical particles were obtained, with average diameters ranging from 53.3 nm to 181.7 nm, depending on the type of coating agent used and the presence of OPE in the reaction mixture. The nanosystems were significantly affected by the gastrointestinal conditions. Bioaccessibility ranged from 33.57% to 56.93% and it was significantly increased by functionalization of with OPE. Biocompatibility was investigated in the HepG2 and Caco2 cell models, proving that they had significantly lower toxicity in comparison to sodium selenite. Significant differences were observed in cellular responses depending on the type of cells used, indicating differences in the mechanisms of toxicity induced by SeNPs. The obtained results provide new insight into the possibilities for the utilization of valuable food-waste extracts in the sustainable development of nanonutraceuticals.
selenium nanoparticles ; olive pomace ; polyphenols ; bioaccessibility ; biocompatibility
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
23 (16)
2022.
9128
16
objavljeno
1422-0067
10.3390/ijms23169128
Trošak objave rada u otvorenom pristupu
Povezanost rada
Farmacija, Interdisciplinarne biotehničke znanosti